Virginia Tech vs Vanderbilt Prediction, Odds, Picks, Best Bets for Week 2 2025

The Saturday slate in college football includes a matchup between the Virginia Tech Hokies and the Vanderbilt Commodores.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important info about today's NCAA football betting odds.

Virginia Tech vs Vanderbilt Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Virginia Tech: (-128) | Vanderbilt: (+106)
• Spread: Virginia Tech: -2.5 (-105) | Vanderbilt: +2.5 (-115)
• Total: 47.5 -- Over: (-110) | Under: (-110)

Virginia Tech vs Vanderbilt Betting Trends

• Virginia Tech hasn't won a game against the spread this season.
• Vanderbilt has posted one win against the spread this year.
• None of Vanderbilt's one games has hit the over in 2025.

Virginia Tech vs Vanderbilt Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hokies win (59.7%)

Virginia Tech vs Vanderbilt Point Spread

Vanderbilt is a 2.5-point underdog against Virginia Tech. Vanderbilt is -115 to cover the spread, and Virginia Tech is -105.

Virginia Tech vs Vanderbilt Over/Under

Virginia Tech versus Vanderbilt, on Sept. 6, has an over/under of 47.5, with the over being -110 and the under -110.

Virginia Tech vs Vanderbilt Moneyline

Looking at the moneyline for Virginia Tech-Vanderbilt, Virginia Tech is the favorite at -128, and Vanderbilt is +106.

Virginia Tech vs. Vanderbilt Points Insights

• The average implied total for the Hokies last season was 30.1 points, 5.1 more points than their implied total of 25 points in Saturday's game.
• The average implied point total last season for the Commodores (32.1) is 9.1 more points than the team's implied total in this matchup (23).

Virginia Tech vs. Vanderbilt Game Info

• Game day: Saturday, September 6, 2025
• Game time: 7:30 p.m. ET
• TV channel: ACC Network
• Location: Blacksburg, Virginia
• Stadium: Lane Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Virginia Tech vs. Vanderbilt analysis on FanDuel Research.