Vanderbilt vs Wake Forest College Basketball Prediction, Odds, Picks, Best Bets for Dec. 21

Two streaking teams hit the court when the Vanderbilt Commodores (11-0) visit the Wake Forest Demon Deacons (9-3) on December 21, 2025. The Commodores will put their 11-game win streak on the line against the Demon Deacons, winners of three straight.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Vanderbilt vs. Wake Forest Game Info and Odds

• Game day: Sunday, December 21, 2025
• Game time: 1 p.m. ET
• TV channel: The CW Network
• Location: Winston-Salem, North Carolina
• Arena: Lawrence Joel Veterans Memorial Coliseum

Vanderbilt vs. Wake Forest Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Vanderbilt win (55.7%)

Before you place a wager on Vanderbilt-Wake Forest matchup (in which Vanderbilt is a 4.5-point favorite and the over/under has been set at 160.5 points), below are some betting trends and insights for Sunday's game.

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Vanderbilt vs. Wake Forest: ATS Betting Stats and Trends

• Vanderbilt has compiled a 6-5-0 record against the spread this season.
• Wake Forest has won six games against the spread this season, while failing to cover six times.
• As a 4.5-point underdog or more in 2025-26, Wake Forest is 2-0 against the spread compared to the 6-5 ATS record Vanderbilt racks up as a 4.5-point favorite.
• The Commodores covered the spread in a higher percentage of their home games than road games last season. They covered 11 times in 17 opportunities when playing at home, and they covered five times in 10 opportunities in road games.
• The Demon Deacons' winning percentage against the spread at home was .375 (6-10-0) last year. Away, it was .500 (6-6-0).

Vanderbilt vs. Wake Forest: Moneyline Betting Stats

• Vanderbilt has yet to lose any of the eight games it has been chosen as the moneyline favorite in this season.
• The Commodores have not lost in seven games this year when favored by -225 or better on the moneyline.
• Wake Forest has won one of the three games it was the underdog on the moneyline this season (33.3%).
• The Demon Deacons have played as a moneyline underdog of +184 or longer in just two games this season, which they lost both.
• Vanderbilt has an implied victory probability of 69.2% according to the moneyline set for this matchup.

Vanderbilt vs. Wake Forest Head-to-Head Comparison

• Vanderbilt's +232 scoring differential (outscoring opponents by 21.1 points per game) is a result of scoring 93.7 points per game (seventh in college basketball) while giving up 72.6 per contest (165th in college basketball).
• Duke Miles ranks 126th in the nation with a team-high 17.1 points per game.
• Wake Forest is outscoring opponents by 13 points per game, with a +156 scoring differential overall. It puts up 85.3 points per game (58th in college basketball) and gives up 72.3 per outing (157th in college basketball).
• Juke Harris' team-leading 20 points per game rank him 33rd in college basketball.
• The Commodores are 69th in the country at 36.1 rebounds per game. That's 7.5 more than the 28.6 their opponents average.
• Devin is 152nd in college basketball action with 7.1 rebounds per game to lead the Commodores.
• The Demon Deacons win the rebound battle by 1.4 boards on average. They record 33.1 rebounds per game, 189th in college basketball, while their opponents grab 31.7.
• Harris' 6.8 rebounds per game lead the Demon Deacons and rank 184th in the country.
• Vanderbilt averages 112.5 points per 100 possessions on offense (eighth in college basketball), and gives up 87.2 points per 100 possessions (74th in college basketball).
• The Demon Deacons score 102.3 points per 100 possessions (92nd in college basketball), while allowing 86.7 points per 100 possessions (66th in college basketball).

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