Vanderbilt vs SMU College Basketball Prediction, Odds, Picks, Best Bets for Dec. 3

The Vanderbilt Commodores (8-0) bring an eight-game win streak into a home matchup with the SMU Mustangs (8-0), winners of eight straight as well.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Vanderbilt vs. SMU Game Info and Odds

• Game day: Wednesday, December 3, 2025
• Game time: 9:15 p.m. ET
• TV channel: SEC Network
• Location: Nashville, Tennessee
• Arena: Memorial Gymnasium

Vanderbilt vs. SMU Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Vanderbilt win (71.7%)

Vanderbilt is a 10.5-point favorite against SMU on Wednesday and the over/under is set at 167.5 points. Keep reading for a few betting insights and trends if you plan to place a wager on the outing.

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Vanderbilt vs. SMU: ATS Betting Stats and Trends

• Vanderbilt has covered five times in eight matchups with a spread this season.
• SMU is 4-4-0 ATS this season.
• Against the spread last season, the Commodores played better when playing at home, covering 11 times in 17 home games, and five times in 10 road games.
• Against the spread last season, the Mustangs had better results away (5-6-0) than at home (7-10-0).

Vanderbilt vs. SMU: Moneyline Betting Stats

• Vanderbilt has been listed as the moneyline favorite six times this season and has come away with a win in all of those games.
• The Commodores have not lost in four games this year when favored by -610 or better on the moneyline.
• SMU has been listed as the moneyline underdog just one other time so far this season, a game it won.
• The Mustangs have not played a game this season with moneyline odds of +440 or longer.
• The moneyline set for this matchup implies Vanderbilt has a 85.9% chance of coming away with a victory in the contest.

Vanderbilt vs. SMU Head-to-Head Comparison

• Last year, Vanderbilt was 55th in the nation on offense (78.9 points scored per game) and 249th on defense (74.3 points allowed).
• Vanderbilt was 221st in college basketball in rebounds per game (31.2) and 226th in rebounds allowed (31.9) last year.
• Last season Vanderbilt was ranked 158th in the nation in assists with 13.8 per game.
• In terms of turnovers, Vanderbilt was 40th in the nation in committing them (9.6 per game) last year. It was 40th in forcing them (13.4 per game).
• On offense, SMU scored 79.9 points per game (40th-ranked in college basketball) last year. It gave up 71.3 points per contest at the other end (152nd-ranked).
• Last season SMU averaged 34.7 rebounds per game (43rd-ranked in college basketball) and gave up 29 rebounds per contest (53rd-ranked).
• SMU ranked 42nd in the nation with 15.9 assists per contest.
• SMU committed 11.5 turnovers per game (221st-ranked in college basketball) this season, while forcing 12 turnovers per contest (112th-ranked).

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