Vanderbilt vs Iowa Prediction, Odds, Picks, Best Bets for ReliaQuest Bowl 2025

The Vanderbilt Commodores will face the Iowa Hawkeyes in college football action on Wednesday.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important information about today's NCAA football betting odds.

Vanderbilt vs Iowa Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Vanderbilt: (-210) | Iowa: (+172)
• Spread: Vanderbilt: -5.5 (-110) | Iowa: +5.5 (-110)
• Total: 46.5 -- Over: (-115) | Under: (-105)

Vanderbilt vs Iowa Betting Trends

• Vanderbilt has 10 wins in 12 games against the spread this year.
• Vanderbilt owns an ATS record of 4-1 as 5.5-point or greater favorites.
• Vanderbilt has played 12 games this year, and eight of them have hit the over.
• Iowa's record against the spread in 2025 is 9-3-0.
• Iowa has covered every time (3-0) as a 5.5-point or greater underdog this season.
• Of 12 Iowa games so far this season, five have gone over the total.

Vanderbilt vs Iowa Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Commodores win (63.8%)

Vanderbilt vs Iowa Point Spread

Vanderbilt is favored by 5.5 points over Iowa. Vanderbilt is -110 to cover the spread, with Iowa being -110.

Vanderbilt vs Iowa Over/Under

Vanderbilt versus Iowa, on Dec. 31, has an over/under of 46.5, with the over being -115 and the under -105.

Vanderbilt vs Iowa Moneyline

Looking at the moneyline for Vanderbilt-Iowa, Vanderbilt is the favorite at -210, and Iowa is +172.

Vanderbilt vs. Iowa Points Insights

Vanderbilt vs. Iowa Game Info

• Game day: Wednesday, December 31, 2025
• Game time: 12 p.m. ET
• TV channel: ESPN
• Location: Tampa, Florida
• Stadium: Raymond James Stadium

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