Vanderbilt vs Iowa Prediction, Odds, Picks, Best Bets for ReliaQuest Bowl 2025

College football's Wednesday schedule includes the Vanderbilt Commodores taking on the Iowa Hawkeyes.

We've got you covered, in terms of the vital info regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Vanderbilt vs Iowa Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Vanderbilt: (-200) | Iowa: (+168)
• Spread: Vanderbilt: -5.5 (-105) | Iowa: +5.5 (-115)
• Total: 45.5 -- Over: (-106) | Under: (-114)

Vanderbilt vs Iowa Betting Trends

• Vanderbilt's record against the spread is 10-2-0.
• For the season, Vanderbilt is 4-1 as 5.5-point or better favorites.
• This season, eight of Vanderbilt's 12 games have hit the over.
• Iowa's record against the spread in 2025 is 9-3-0.
• Iowa is unbeaten ATS (3-0) as a 5.5-point underdog or greater this season.
• This season, five of Iowa's 12 games have hit the over.

Vanderbilt vs Iowa Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Commodores win (63.9%)

Vanderbilt vs Iowa Point Spread

Iowa is a 5.5-point underdog against Vanderbilt. Iowa is -115 to cover the spread, and Vanderbilt is -105.

Vanderbilt vs Iowa Over/Under

Vanderbilt versus Iowa, on Dec. 31, has an over/under of 45.5, with the over being -106 and the under -114.

Vanderbilt vs Iowa Moneyline

Looking at the moneyline for Iowa-Vanderbilt, Iowa is the underdog at +168, and Vanderbilt is -200.

Vanderbilt vs. Iowa Points Insights

Vanderbilt vs. Iowa Game Info

• Game day: Wednesday, December 31, 2025
• Game time: 12 p.m. ET
• TV channel: ESPN
• Location: Tampa, Florida
• Stadium: Raymond James Stadium

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