USC vs UCLA Prediction, Odds, Picks, Best Bets for Week 14 2025

In college football action on Saturday, the USC Trojans play the UCLA Bruins.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

USC vs UCLA Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: USC: (-2222) | UCLA: (+1100)
• Spread: USC: -21.5 (-114) | UCLA: +21.5 (-106)
• Total: 59.5 -- Over: (-105) | Under: (-115)

USC vs UCLA Betting Trends

• USC has five wins in 11 games against the spread this year.
• USC has yet to lose ATS (2-0) as a 21.5-point favorite or greater this season.
• USC has played 11 games this year, and six of them have gone over the total.
• UCLA has three wins in 11 contests against the spread this year.
• UCLA has one win ATS (1-2) as a 21.5-point underdog or more this year.
• UCLA has played 11 games this year, and six of them have hit the over.

USC vs UCLA Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Trojans win (95.7%)

USC vs UCLA Point Spread

USC is a 21.5-point favorite against UCLA. USC is -114 to cover the spread, and UCLA is -106.

USC vs UCLA Over/Under

A combined point total of 59.5 has been set for USC-UCLA on Nov. 29, with the over at -105 and the under at -115.

USC vs UCLA Moneyline

USC is a -2222 favorite on the moneyline, while UCLA is a +1100 underdog.

USC vs. UCLA Points Insights

USC vs. UCLA Game Info

• Game day: Saturday, November 29, 2025
• Game time: 7:30 p.m. ET
• TV channel: NBC
• Location: Los Angeles, California
• Stadium: Los Angeles Memorial Coliseum

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Check out even more in-depth USC vs. UCLA analysis on FanDuel Research.