USC vs Missouri State Prediction, Odds, Picks, Best Bets for Week 1 2025

The USC Trojans will face the Missouri State Bears in college football action on Saturday.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

USC vs Missouri State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: USC: (-33333) | Missouri State: (+4000)
• Spread: USC: -36.5 (-110) | Missouri State: +36.5 (-110)
• Total: 59.5 -- Over: (-115) | Under: (-105)

USC vs Missouri State Betting Trends

• USC was 8-5-0 against the spread last year.
• Last season, six of USC's 13 games went over the point total.
• Missouri State posted a 5-6-0 record against the spread last year.
• In 11 Missouri State games last year, seven of them hit the over.

USC vs Missouri State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Trojans win (97.7%)

USC vs Missouri State Point Spread

USC is favored by 36.5 points (-110 to cover) in this matchup. Missouri State, the underdog, is -110.

USC vs Missouri State Over/Under

A total of 59.5 points has been set for the USC-Missouri State matchup on Aug. 30, with the over available at -115 and the under at -105.

USC vs Missouri State Moneyline

Missouri State is a +4000 underdog on the moneyline, while USC is a -33333 favorite.

USC vs. Missouri State Points Insights

• The Trojans had an average implied point total of 31.2 last season, which is 16.8 points lower than their implied total in Saturday's game (48).
• The 34.2-point average implied total last season for the Bears is 22.2 more points than the team's 12-point implied total in this matchup.

USC vs. Missouri State Game Info

• Game day: Saturday, August 30, 2025
• Game time: 7:30 p.m. ET
• TV channel: BTN
• Location: Los Angeles, California
• Stadium: Los Angeles Memorial Coliseum

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Check out even more in-depth USC vs. Missouri State analysis on FanDuel Research.