USC vs Iowa Prediction, Odds, Picks, Best Bets for Week 12 2025

The USC Trojans versus the Iowa Hawkeyes is on the college football schedule for Saturday.

We've got you covered, in terms of the most important information regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

USC vs Iowa Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: USC: (-240) | Iowa: (+194)
• Spread: USC: -6.5 (-115) | Iowa: +6.5 (-105)
• Total: 48.5 -- Over: (-115) | Under: (-105)

USC vs Iowa Betting Trends

• USC is 5-4-0 against the spread this season.
• This season, USC is 3-3 as 6.5-point or better favorites.
• This season, five of USC's nine games have go over the point total.
• Against the spread, Iowa is 7-2-0 this season.
• Iowa is unbeaten ATS (1-0) as a 6.5-point underdog or more this season.
• There have been four Iowa games (out of nine) that hit the over this year.

USC vs Iowa Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Trojans win (67.4%)

USC vs Iowa Point Spread

Iowa is listed as an underdog by 6.5 points (-105 odds), and USC, the favorite, is -115 to cover.

USC vs Iowa Over/Under

USC versus Iowa on Nov. 15 has an over/under of 48.5 points, with the over -115 and the under -105.

USC vs Iowa Moneyline

Looking at the moneyline for Iowa-USC, Iowa is the underdog at +194, and USC is -240.

USC vs. Iowa Points Insights

USC vs. Iowa Game Info

• Game day: Saturday, November 15, 2025
• Game time: 3:30 p.m. ET
• TV channel: BTN
• Location: Los Angeles, California
• Stadium: Los Angeles Memorial Coliseum

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