Trail Blazers vs. Pistons Prediction, Odds, Picks, Best Bets for Dec. 22

Trail Blazers vs. Pistons Game Info

• Date: Monday, December 22, 2025
• Time: 10 p.m. ET
• Venue: Moda Center -- Portland, Oregon
• Coverage: KUNP and FDSDET

The Portland Trail Blazers (12-16) are 6-point underdogs as they attempt to build on a three-game winning streak when they host the Detroit Pistons (22-6) on Monday, December 22, 2025 at Moda Center. The contest airs at 10 p.m. ET on KUNP and FDSDET. The over/under is set at 234.5 in the matchup.

Trail Blazers vs. Pistons Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Trail Blazers vs. Pistons Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Pistons win (66%)

Trail Blazers vs. Pistons Betting Trends

• The Pistons have covered the spread in a game 16 times this season (16-12-0).
• Against the spread, the Trail Blazers are 15-13-0 this season.
• Pistons games have finished with a final combined score above the over/under 15 times this season.
• Trail Blazers games this season have gone over the total in 18 of 28 opportunities (64.3%).
• In home games, Detroit sports a better record against the spread (9-6-0) compared to its ATS record in away games (7-6-0).
• The Pistons have gone over the total more consistently when playing at home, hitting the over in nine of 15 home matchups (60%). In away games, they have hit the over in six of 13 games (46.2%).
• Against the spread, Portland has performed better at home (7-4-0) than on the road (8-9-0).
• Looking at the over/under, Trail Blazers games have finished over eight of 11 times at home (72.7%), and 10 of 17 on the road (58.8%).

Pistons Leaders

• Cade Cunningham is averaging 27 points, 9.2 assists and 6.4 rebounds.
• Jalen Duren is averaging 18 points, 11 rebounds and 1.7 assists. At the other end, he averages 0.9 steals and 0.9 blocked shots.
• Ausar Thompson's numbers on the season are 11.5 points, 5.7 boards and 2.8 assists per game, shooting 52.1% from the field.
• Isaiah Stewart is averaging 10.3 points, 6.2 rebounds and 1.2 assists. At the other end, he averages 0.2 steals and 1.9 blocked shots (second in league).
• Duncan Robinson is averaging 12 points, 2.9 rebounds and 1.9 assists.

Trail Blazers Leaders

• Deni Avdija averages 25.8 points for the Trail Blazers, plus 7.1 boards and 6.4 assists.
• The Trail Blazers are receiving 20 points, 4 rebounds and 2.7 assists per game from Jerami Grant.
• Per game, Shaedon Sharpe provides the Trail Blazers 22 points, 4.5 boards and 2.5 assists, plus 1.4 steals and 0.2 blocks.
• Toumani Camara's numbers on the season are 12.6 points, 5.3 rebounds and 2.9 assists per game. He is making 41.6% of his shots from the field and 34.2% from 3-point range, with an average of 2.4 triples.
• The Trail Blazers are receiving 10.3 points, 10.3 rebounds and 1.8 assists per game from Donovan Clingan.

For more NBA betting insights, check out FanDuel Research's NBA home page.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Watch FanDuel TV's NBA show "Run It Back" with Lou Williams, Michelle Beadle, DeMarcus "Boogie" Cousins and Chandler Parsons weekdays at 10am ET on FanDuel TV, the Run It Back YouTube page, or download the podcast here: fanduel.com/research/tv-and-podcast.