Tigers vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 5

Odds updated as of 2:12 a.m.

In MLB action on Friday, the Detroit Tigers play the Chicago White Sox.

We've got you covered, in terms of the vital info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Tigers vs White Sox Game Info

• Detroit Tigers (81-60) vs. Chicago White Sox (53-88)
• Date: Friday, September 5, 2025
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: FDSDET and CHSN

Tigers vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-190) | CHW: (+160)
• Spread: DET: -1.5 (+106) | CHW: +1.5 (-128)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Tigers vs White Sox Probable Starting Pitchers

Probable Pitchers: Jack Flaherty (Tigers) - 7-13, 4.74 ERA vs Shane Smith (White Sox) - 4-7, 3.81 ERA

This contest's pitching matchup is set, as the Tigers will send Jack Flaherty (7-13) to the mound, while Shane Smith (4-7) will get the nod for the White Sox. Flaherty's team is 9-17-0 against the spread this season in his starts. Flaherty's team has won 41.2% of his starts when they are favored on the moneyline (7-10). The White Sox have gone 12-12-0 ATS in Smith's 24 starts with a set spread. The White Sox have been the moneyline underdog in 22 of Smith's starts this season, and they went 6-16 in those matchups.

Tigers vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (68.3%)

Tigers vs White Sox Moneyline

• The Tigers vs White Sox moneyline has Detroit as a -190 favorite, while Chicago is a +160 underdog on the road.

Tigers vs White Sox Spread

• The Tigers are favored by 1.5 runs at home against the White Sox. The Tigers are +106 to cover the spread, while the White Sox are -128.

Tigers vs White Sox Over/Under

• Tigers versus White Sox on Sept. 5 has an over/under of 8.5 runs, with the odds on the over -102 and the under set at -120.

Bet on Detroit Tigers vs. Chicago White Sox on FanDuel today!

Tigers vs White Sox Betting Trends

• The Tigers have won in 56, or 61.5%, of the 91 contests they have been named as odds-on favorites in this year.
• This season Detroit has been victorious 16 times in 23 chances when named as a favorite of at least -190 on the moneyline.
• The Tigers and their opponents have hit the over in 67 of their 135 games with a total set by oddsmakers this season.
• In 135 games with a line this season, the Tigers have a mark of 65-70-0 against the spread.
• The White Sox have won 36.8% of the games this season they were the underdog on the moneyline (49-84).
• Chicago has a 13-36 record (winning just 26.5% of its games) when it has played as a moneyline underdog of +160 or longer.
• The White Sox have played in 136 games with an over/under set, and have combined with their opponents to go over the total 63 times (63-65-8).
• The White Sox have covered 56.6% of their games this season, going 77-59-0 ATS.

Tigers Player Leaders

• Riley Greene has 141 hits to go with a slugging percentage of .511, both of which rank first among Detroit hitters this season. He has a .269 batting average and an on-base percentage of .324.
• Among qualifying hitters in the majors, his batting average ranks 47th, his on-base percentage ranks 88th, and he is 16th in slugging.
• Gleyber Torres leads Detroit in OBP (.364) this season, fueled by 119 hits. He's batting .261 while slugging .395.
• Among qualified hitters, his batting average ranks him 73rd, his on-base percentage 21st, and his slugging percentage 114th.
• Spencer Torkelson has collected 116 base hits, an OBP of .332 and a slugging percentage of .466 this season.
• Torkelson heads into this game with three games in a row with at least one hit. During his last five outings he is hitting .222 with two walks and an RBI.
• Zach McKinstry is batting .267 with a .346 OBP and 46 RBI for Detroit this season.
• McKinstry heads into this matchup on a four-game hitting streak. In his last five games he is hitting .429 with a double, a triple, two walks and three RBIs.

White Sox Player Leaders

• Andrew Benintendi is batting .244 with 15 doubles, two triples, 17 home runs and 35 walks. He's slugging .424 with an on-base percentage of .307.
• Lenyn Sosa leads his team with 119 hits and has a club-best .430 slugging percentage. He has a batting average of .263 with an on-base percentage of .294.
• He is currently 65th in batting average, 138th in on-base percentage and 80th in slugging percentage among all qualifying hitters.
• Chase Meidroth is batting .258 with 15 doubles, four home runs and 38 walks.
• Mike Tauchman has 15 doubles, a triple, eight home runs and 40 walks while hitting .271.

Tigers vs White Sox Head to Head

• 8/13/2025: 1-0 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/12/2025: 9-6 CHW (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 8/11/2025: 2-1 DET (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/5/2025: 3-2 CHW (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/3/2025: 8-1 CHW (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/2/2025: 13-1 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -240, Underdog Moneyline: +194)
• 4/6/2025: 4-3 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 4/5/2025: 7-2 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 4/4/2025: 7-4 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 9/29/2024: 9-5 CHW (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -240, Underdog Moneyline: +198)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!