St. John's vs DePaul College Basketball Prediction, Odds, Picks, Best Bets for Dec. 16

The DePaul Blue Demons (8-3, 0-0 Big East) aim to extend a three-game win streak when they visit the St. John's Red Storm (6-3, 0-0 Big East) on December 16, 2025 at Carnesecca Arena. The contest airs on Peacock.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

St. John's vs. DePaul Game Info and Odds

• Game day: Tuesday, December 16, 2025
• Game time: 7 p.m. ET
• TV channel: Peacock
• Location: Queens, New York
• Arena: Carnesecca Arena

If you plan to place a wager on St. John's-DePaul matchup (in which St. John's is a 19.5-point favorite and the over/under is set at 147.5 points), below are a few betting insights and trends for Tuesday's game.

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St. John's vs. DePaul: ATS Betting Stats and Trends

• St. John's has put together a 5-4-0 record against the spread this season.
• DePaul is 6-5-0 ATS this year.
• The Red Storm covered the spread in a lower percentage of their home games than road games last year. They covered 10 times in 18 games at home, and they covered six times in 10 games when playing on the road.
• In 2024-25 against the spread, the Blue Demons had a better winning percentage at home (.474, 9-10-0 record) than on the road (.417, 5-7-0).

St. John's vs. DePaul: Moneyline Betting Stats

• St. John's has come away with five wins in the seven contests it has been listed as the moneyline favorite in this season.
• The Red Storm have been a -4000 moneyline favorite on three occasions this season and won every game.
• DePaul has won 33.3% of the games this season it was the moneyline underdog (1-2).
• The Blue Demons have never played a game this season with moneyline odds of +1400 or longer.
• The moneyline set for this matchup implies St. John's has a 97.6% chance of coming away with a victory in the contest.

St. John's vs. DePaul Head-to-Head Comparison

• St. John's averages 88.9 points per game (26th in college basketball) while allowing 73.0 per outing (178th in college basketball). It has a +143 scoring differential overall and outscores opponents by 15.9 points per game.
• Bryce Hopkins' team-leading 14.9 points per game ranks 292nd in the country.
• DePaul outscores opponents by 9.6 points per game (posting 77.4 points per game, 187th in college basketball, and conceding 67.8 per contest, 69th in college basketball) and has a +105 scoring differential.
• CJ Gunn's team-leading 14.2 points per game rank him 365th in college basketball.
• The Red Storm prevail in the rebound battle by an average of 5.6 boards. They are grabbing 36.7 rebounds per game (50th in college basketball) compared to their opponents' 31.1 per outing.
• Zuby Ejiofor tops the team with 7.2 rebounds per game (138th in college basketball play).
• The 31.1 rebounds per game the Blue Demons accumulate rank 274th in the nation. Their opponents grab 30.3.
• N.J. Benson tops the Blue Demons with 6.6 rebounds per game (221st in college basketball).
• St. John's ranks 97th in college basketball with 102.2 points scored per 100 possessions, and 39th in college basketball defensively with 84.0 points conceded per 100 possessions.
• The Blue Demons rank 149th in college basketball with 99.0 points scored per 100 possessions, and 81st defensively with 86.8 points conceded per 100 possessions.

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