South Florida vs Old Dominion Prediction, Odds, Picks, Best Bets for Cure Bowl 2025

College football's Wednesday schedule includes the South Florida Bulls taking on the Old Dominion Monarchs.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

South Florida vs Old Dominion Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: South Florida: (-300) | Old Dominion: (+240)
• Spread: South Florida: -7.5 (-110) | Old Dominion: +7.5 (-110)
• Total: 55.5 -- Over: (-106) | Under: (-114)

South Florida vs Old Dominion Betting Trends

• South Florida has beaten the spread nine times in 12 games.
• South Florida's ATS record as 7.5-point or bigger favorites is 6-1.
• This year, seven of South Florida's 12 games have gone over the point total.
• Old Dominion's record against the spread in 2025 is 7-5-0.
• Old Dominion has yet to lose ATS (1-0) as a 7.5-point underdog or more this season.
• Old Dominion has played 12 games this year, and five of them have hit the over.

South Florida vs Old Dominion Point Spread

Old Dominion is the underdog by 7.5 points against South Florida. Old Dominion is -110 to cover the spread, and South Florida is -110.

South Florida vs Old Dominion Over/Under

An over/under of 55.5 has been set for South Florida-Old Dominion on Dec. 17, with the over being -106 and the under -114.

South Florida vs Old Dominion Moneyline

South Florida is the favorite, -300 on the moneyline, while Old Dominion is a +240 underdog.

South Florida vs. Old Dominion Points Insights

South Florida vs. Old Dominion Game Info

• Game day: Wednesday, December 17, 2025
• Game time: 5 p.m. ET
• TV channel: ESPN
• Location: Orlando, Florida
• Stadium: Camping World Stadium

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