Reds vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 29

Odds updated as of 6:18 p.m.

Friday's slate in the MLB includes a matchup between the Cincinnati Reds and the St. Louis Cardinals.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Reds vs Cardinals Game Info

• Cincinnati Reds (68-66) vs. St. Louis Cardinals (66-69)
• Date: Friday, August 29, 2025
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and FDSMW

Reds vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-142) | STL: (+120)
• Spread: CIN: -1.5 (+146) | STL: +1.5 (-178)
• Total: 8.5 -- Over: (-122) | Under: (-100)

Reds vs Cardinals Probable Starting Pitchers

Probable Pitchers: Zack Littell (Reds) - 9-8, 3.62 ERA vs Matthew Liberatore (Cardinals) - 6-11, 4.27 ERA

This contest's pitching matchup is set, as the Reds will send Zack Littell (9-8) to the mound, while Matthew Liberatore (6-11) will answer the bell for the Cardinals. Littell's team is 13-13-0 against the spread this season in his starts. Littell's team has won 55.6% of his starts when they are favored on the moneyline (5-4). The Cardinals have gone 11-11-0 against the spread when Liberatore starts. The Cardinals are 7-2 in Liberatore's nine starts this season that they were the underdog on the moneyline.

Reds vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (55.2%)

Reds vs Cardinals Moneyline

• Cincinnati is the favorite, -142 on the moneyline, while St. Louis is a +120 underdog on the road.

Reds vs Cardinals Spread

• The Reds are favored by 1.5 runs at home versus the Cardinals. The Reds are +146 to cover the spread, while the Cardinals are -178.

Reds vs Cardinals Over/Under

• A combined run total of 8.5 has been set for Reds-Cardinals on Aug. 29, with the over at -122 and the under at -100.

Bet on Cincinnati Reds vs. St. Louis Cardinals on FanDuel today!

Reds vs Cardinals Betting Trends

• The Reds have been favorites in 52 games this season and have come away with the win 28 times (53.8%) in those contests.
• This season Cincinnati has come away with a win nine times in 18 chances when named as a favorite of at least -142 on the moneyline.
• The Reds' games have gone over the total in 49 of their 127 opportunities.
• In 127 games with a line this season, the Reds have a mark of 67-60-0 against the spread.
• The Cardinals have gone 33-36 in games they were the underdog on the moneyline (winning 47.8% of those games).
• St. Louis is 11-17 (winning just 39.3% of its games) when playing as a moneyline underdog of +120 or longer.
• The Cardinals have played in 129 games with a set over/under, and have combined with opponents to go over the total 67 times (67-57-5).
• The Cardinals have a 65-64-0 record ATS this season.

Reds Player Leaders

• Elly De La Cruz leads Cincinnati in slugging percentage (.450) and total hits (142) this season. He's batting .272 with an on-base percentage of .343.
• Among all qualifying hitters in the majors, he is 40th in batting average, 52nd in on-base percentage, and 63rd in slugging.
• De La Cruz has picked up at least one hit in two straight games. During his last five outings he is hitting .227 with a double.
• TJ Friedl leads Cincinnati with an OBP of .364 this season while batting .266 with 62 walks and 70 runs scored. He's slugging .376.
• He ranks 56th in batting average, 18th in on-base percentage and 135th in slugging in MLB.
• Friedl takes a three-game streak with at least one hit into this matchup. During his last five outings he is hitting .238 with two walks and an RBI.
• Spencer Steer is batting .235 with a .396 slugging percentage and 62 RBI this year.
• Austin Hays is batting .266 with a .323 OBP and 53 RBI for Cincinnati this season.

Cardinals Player Leaders

• Willson Contreras is batting .255 with 30 doubles, 19 home runs and 40 walks. He's slugging .448 with an on-base percentage of .340.
• Including all qualified hitters in MLB, his batting average puts him 88th, his on-base percentage ranks 55th, and he is 68th in slugging.
• Masyn Winn is hitting .254 with 26 doubles, nine home runs and 32 walks. He's slugging .370 with an on-base percentage of .311.
• Including all qualified hitters, his batting average puts him 90th, his on-base percentage ranks 112th, and he is 137th in slugging.
• Lars Nootbaar has 21 doubles, 13 home runs and 54 walks while hitting .238.
• Ivan Herrera has 11 doubles, 10 home runs and 30 walks while hitting .281.

Reds vs Cardinals Head to Head

• 6/22/2025: 4-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 6/20/2025: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/1/2025: 9-1 CIN (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/30/2025: 9-1 STL (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2025: 6-0 STL (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/28/2025: 3-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/12/2024: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/11/2024: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/10/2024: 3-0 CIN (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)

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