Red Sox vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 5

Odds updated as of 9:12 p.m.

The Friday slate in MLB includes a matchup between the Boston Red Sox and the Arizona Diamondbacks.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Diamondbacks Game Info

• Boston Red Sox (78-63) vs. Arizona Diamondbacks (70-71)
• Date: Friday, September 5, 2025
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and NESN

Red Sox vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-134) | ARI: (+114)
• Spread: BOS: -1.5 (+120) | ARI: +1.5 (-144)
• Total: 9 -- Over: (-105) | Under: (-115)

Red Sox vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Payton Tolle (Red Sox) - 0-0, 3.38 ERA vs Eduardo Rodríguez (Diamondbacks) - 6-8, 5.40 ERA

The Red Sox will give the nod to Payton Tolle against the Diamondbacks and Eduardo Rodriguez (6-8). Tolle and his team failed to cover the spread in his only opportunity this season as a starter. Tolle's team lost his only start as a favorite this season. When Rodriguez starts, the Diamondbacks are 8-15-0 against the spread. The Diamondbacks have been the moneyline underdog in nine of Rodríguez's starts this season, and they went 4-5 in those matchups.

Red Sox vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (51.7%)

Red Sox vs Diamondbacks Moneyline

• The moneyline numbers for Red Sox vs. Diamondbacks reveal Boston as the favorite (-134) and Arizona as the underdog (+114) despite being the home team.

Red Sox vs Diamondbacks Spread

• The Red Sox are favored by 1.5 runs on the road against the Diamondbacks. The Red Sox are +120 to cover the spread, while the Diamondbacks are -144.

Red Sox vs Diamondbacks Over/Under

• The over/under for Red Sox-Diamondbacks on Sept. 5 is 9. The over is -105, and the under is -115.

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Red Sox vs Diamondbacks Betting Trends

• The Red Sox have come away with 52 wins in the 88 contests they have been listed as the favorites in this season.
• Boston has a record of 26-19 in contests when sportsbooks favor them by -134 or more on the moneyline.
• The Red Sox and their opponents have gone over in 67 of their 140 games with a total set by sportsbooks this season.
• The Red Sox are 76-64-0 against the spread in their 140 games with a line set by sportsbooks this season.
• The Diamondbacks have been the underdog on the moneyline 55 total times this season. They've finished 26-29 in those games.
• When playing as a moneyline underdog with odds of +114 or longer, Arizona has a 16-12 record (winning 57.1% of its games).
• The Diamondbacks have had an over/under set by oddsmakers 137 times, and have combined with opponents to go over the total in 67 of those games (67-64-6).
• The Diamondbacks have collected a 67-70-0 record against the spread this season (covering 48.9% of the time).

Red Sox Player Leaders

• Jarren Duran leads Boston in OBP (.337), slugging percentage (.449) and total hits (140) this season. He has a .260 batting average.
• He ranks 77th in batting average, 62nd in on-base percentage, and 62nd in slugging among qualified hitters in baseball.
• Duran hopes to build on a two-game hitting streak in this matchup. During his last five outings he is hitting .333 with two doubles, a home run, three walks and four RBIs.
• Trevor Story is batting .259 with 24 doubles, 23 home runs and 30 walks. He's slugging .436 with an on-base percentage of .306.
• Among all qualifying players, he ranks 81st in batting average, 122nd in on-base percentage and 76th in slugging percentage.
• Ceddanne Rafaela is batting .248 with a .423 slugging percentage and 60 RBI this year.
• Alex Bregman has 16 home runs, 54 RBI and a batting average of .281 this season.

Diamondbacks Player Leaders

• Geraldo Perdomo has racked up a slugging percentage of .443, a team-best for the Diamondbacks. He's batting .282 with an on-base percentage of .381.
• Including all the qualifying hitters in the big leagues, his batting average ranks 22nd, his on-base percentage ranks eighth, and he is 73rd in slugging.
• Corbin Carroll has 127 hits to pace his team. He has a batting average of .257 while slugging .555 with an on-base percentage of .333.
• Including all qualifying players, he is 85th in batting average, 70th in on-base percentage and seventh in slugging percentage.
• Ketel Marte has an on-base percentage of .390, a team-best for the Diamondbacks.
• Gabriel Moreno is hitting .278 with 10 doubles, a triple, seven home runs and 15 walks.

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