Rays vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 7

Odds updated as of 11:12 a.m.

The MLB slate on Sunday includes the Tampa Bay Rays taking on the Cleveland Guardians.

We've got you covered, in terms of the most important info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Rays vs Guardians Game Info

• Tampa Bay Rays (71-71) vs. Cleveland Guardians (71-70)
• Date: Sunday, September 7, 2025
• Time: 12:10 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and CLEG

Rays vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-158) | CLE: (+134)
• Spread: TB: -1.5 (+130) | CLE: +1.5 (-156)
• Total: 8 -- Over: (-122) | Under: (-100)

Rays vs Guardians Probable Starting Pitchers

Probable Pitchers: Drew Rasmussen (Rays) - 10-5, 2.74 ERA vs Parker Messick (Guardians) - 1-0, 2.08 ERA

This contest's pitching matchup is set, as the Rays will send Drew Rasmussen (10-5) to the mound, while Parker Messick (1-0) will get the nod for the Guardians. Rasmussen's team is 14-10-0 against the spread in his starts this season. Rasmussen's team has been victorious in 53.3% of the games he's started as the moneyline favorite with a record of 8-7. The Guardians have a 1-2-0 ATS record in Messick's three starts that had a set spread. The Guardians were the underdog on the moneyline for two Messick starts this season -- they lost both.

Rays vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (68.9%)

Rays vs Guardians Moneyline

• The Rays vs Guardians moneyline has Tampa Bay as a -158 favorite, while Cleveland is a +134 underdog on the road.

Rays vs Guardians Spread

• The Guardians are at +1.5 on the runline against the Rays. The Guardians are -156 to cover the spread, and the Rays are +130.

Rays vs Guardians Over/Under

• An over/under of 8 has been set for Rays-Guardians on Sept. 7, with the over being -122 and the under -100.

Bet on Tampa Bay Rays vs. Cleveland Guardians on FanDuel today!

Rays vs Guardians Betting Trends

• The Rays have won in 38, or 58.5%, of the 65 contests they have been named as odds-on favorites in this year.
• Tampa Bay has a record of 8-10 when favored by -158 or more this year.
• The Rays' games have gone over the total in 59 of their 137 opportunities.
• The Rays are 61-76-0 against the spread in their 137 games with a line set by sportsbooks this season.
• The Guardians have won 35 of the 81 games they were listed as the moneyline underdog this season (43.2%).
• Cleveland has a record of 9-16 when playing as a moneyline underdog with odds of +134 or longer (36%).
• The Guardians have played in 138 games with an over/under set, and have combined with opponents to go over the total 62 times (62-70-6).
• The Guardians have put together a 72-66-0 record ATS this season (covering 52.2% of the time).

Rays Player Leaders

• Junior Caminero leads Tampa Bay with 140 hits, batting .261 this season with 66 extra-base hits. He has an on-base percentage of .302 and a slugging percentage of .537.
• Among all qualified hitters in the majors, his batting average ranks 73rd, his on-base percentage ranks 128th, and he is 11th in slugging.
• Yandy Diaz has a slash line of .293/.351/.473 this season and a team-best OPS of .825.
• He ranks 13th in batting average, 40th in on-base percentage and 36th in slugging in the major leagues.
• Diaz enters this game looking to extend his two-game hit streak. During his last five outings he is batting .474 with a double, two walks and an RBI.
• Brandon Lowe is batting .262 with a .487 slugging percentage and 74 RBI this year.
• Chandler Simpson has been key for Tampa Bay with 99 hits, an OBP of .321 plus a slugging percentage of .337.

Guardians Player Leaders

• Jose Ramirez has totaled 146 hits with a .357 on-base percentage, leading the Guardians in both statistics. He's batting .283 and slugging .501.
• Including all the qualified hitters in the majors, he ranks 22nd in batting average, 28th in on-base percentage and 19th in slugging percentage.
• Ramirez brings a three-game hitting streak into this game. In his last five games he is hitting .368 with two doubles, a home run, a walk and five RBIs.
• Steven Kwan is slugging .381 to pace his team. He has a batting average of .275 with an on-base percentage of .333.
• He ranks 31st in batting average, 68th in on-base percentage and 130th in slugging percentage in MLB.
• Kyle Manzardo is hitting .233 with 14 doubles, two triples, 25 home runs and 44 walks.
• Angel Martinez has 21 doubles, a triple, 10 home runs and 17 walks while batting .224.

Rays vs Guardians Head to Head

• 9/6/2025: 3-2 CLE (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/5/2025: 7-1 CLE (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/4/2025: 4-2 TB (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/27/2025: 4-3 CLE (Favorite: Rays, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/26/2025: 3-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/25/2025: 9-0 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/15/2024: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/14/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/13/2024: 3-1 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2024: 5-2 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

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