Penguins vs Flames NHL Prediction, Odds, Picks, Best Bets for Jan. 21

NHL action on Wednesday includes the Pittsburgh Penguins taking on the Calgary Flames.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NHL betting insights.

Penguins vs Flames Game Info

• Pittsburgh Penguins (23-14-11) vs. Calgary Flames (21-23-5)
• Date: Wednesday, January 21, 2026
• Time: 9:30 p.m. ET
• Venue: Scotiabank Saddledome -- Calgary, Alberta
• Coverage: ESPN+

Penguins vs Flames Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Penguins vs Flames Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Penguins win (66.2%)

Penguins vs Flames Puck Line

• The Flames are underdogs by 1.5 goals. The Flames are -250 to cover the spread, and the Penguins are +198.

Penguins vs Flames Over/Under

• A combined goal total of 5.5 has been set for Penguins-Flames on Jan. 21, with the over at -130 and the under at +106.

Penguins vs Flames Moneyline

• The Penguins vs Flames moneyline has Pittsburgh as a -118 favorite, while Calgary is a +100 underdog at home.

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