Patrick Mahomes Fantasy Football Week 6: Stats and Projections vs. Lions

In Week 6 (Sunday at 8:20 p.m. ET), QB Patrick Mahomes and the Kansas City Chiefs will meet the Detroit Lions, who have the 12th-ranked pass defense in the NFL (206.6 yards allowed per game).

Daily fantasy players, is Mahomes worth considering for his upcoming matchup versus the Lions? Keep reading, because we can help you make the right call.

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Patrick Mahomes Week 6 Fantasy Football Projection

• Matchup: Kansas City Chiefs vs. Detroit Lions
• Game Date: October 12, 2025
• Game Time: 8:20 p.m.
• Projected Fantasy Points: 19.3
• Projected Passing Yards: 238.37
• Projected Passing TDs: 1.92
• Projected Rushing Yards: 23.35
• Projected Rushing TDs: 0.22

Projections provided by numberFire

Mahomes Fantasy Performance

• At the QB position, Mahomes has been one of the best players in fantasy, as he ranks second in the NFL with 23.1 fantasy points per game (115.3 total points). Overall, he is second in fantasy points.
• Over his last three games, Mahomes has put up 67.2 fantasy points (22.4 per game), as he's compiled 812 yards on 76-of-115 passing with six touchdowns and one pick. As a runner, he's tacked on 67 rushing yards on 15 carries with one TD.
• The peak of Mahomes' fantasy season was a Week 4 performance against the Baltimore Ravens, a matchup in which he posted 27.3 fantasy points -- 25-of-37 (67.6%), 270 yards, 4 TDs, 0 INTs.
• From a fantasy standpoint, Patrick Mahomes' game against the New York Giants in Week 3 was his worst of the campaign, as he put up 13.2 fantasy points. He threw for 224 yards and one touchdown, and threw zero picks on the day.

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Lions Defensive Performance

• Detroit has not allowed someone to register over 300 yards passing in a game this year.
• The Lions have allowed four players to pass for at least one TD in a game this year.
• Detroit has allowed at least two TD passes to four opposing QBs this year.
• Two players have thrown for at least three touchdowns in a game versus the Lions this year.
• A total of two players have put up more than 100 yards receiving in a game against Detroit this season.
• The Lions have given up a TD reception by seven players this year.
• Detroit has allowed at least two receiving TDs to three players this season.
• The Lions' defense has not allowed a player to pick up over 100 yards rushing in a game this year.
• A total of four players have rushed for at least one touchdown against Detroit this year.
• The Lions have not allowed an opposing player to score more than one rushing TD versus them this year.

Want more data and analysis on Patrick Mahomes? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.