Patrick Mahomes Fantasy Football Week 16: Stats and Projections vs. Titans

Quarterback Patrick Mahomes is looking at a matchup versus the 25th-ranked pass defense in the league (233.0 yards allowed per game) in Week 16, when his Kansas City Chiefs take on the Tennessee Titans, Sunday at 1 p.m. ET.

With Mahomes' next game against the Titans, should you consider him for your DFS lineup? Scroll down for more stats and information.

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Patrick Mahomes Week 16 Fantasy Football Projection

• Matchup: Kansas City Chiefs at Tennessee Titans
• Game Date: December 21, 2025
• Game Time: 1 p.m.
• Projected Fantasy Points: 16.9
• Projected Passing Yards: 242.37
• Projected Passing TDs: 1.22
• Projected Rushing Yards: 27.23
• Projected Rushing TDs: 0.18

Projections provided by numberFire

Mahomes Fantasy Performance

• Mahomes has been one of the best players in fantasy at the QB position this season, ranking second with 20.3 fantasy points per game (284.7 total points). He is second in fantasy points among all players.
• Through his last three games, Mahomes has completed 53-of-95 passes for 610 yards, with four passing touchdowns and four interceptions, resulting in 47.8 total fantasy points (15.9 per game). With his legs, he's added 104 rushing yards on 12 attempts with one TD.
• Mahomes has put up 78.2 fantasy points (15.6 per game) in his last five games, connecting on 111-of-186 throws for 1,238 yards, with five touchdowns and six interceptions. He's added 137 rushing yards on 17 carries with one touchdown on the ground.
• The peak of Mahomes' fantasy season came against the Detroit Lions in Week 6, when he racked up 31.5 fantasy points with 257 passing yards, three TDs, and zero picks. With his legs, he added 32 rushing yards on 10 carries (3.2 YPC) with one touchdown.
• From a fantasy standpoint, Patrick Mahomes had his worst performance of the season in Week 14 against the Houston Texans, when he posted 5.3 fantasy points -- 14-of-33 (42.4%), 160 yards, 0 TDs, 3 INTs; 7 carries, 59 yards.

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Titans Defensive Performance

• Tennessee has allowed just one player to record over 300 yards passing in a game this year.
• The Titans have allowed 13 players to pass for at least one TD in a game this season.
• Tennessee has allowed nine players to throw for at least two TDs in a game this year.
• The Titans have allowed three or more passing TDs to three opposing QBs this year.
• Tennessee has allowed over 100 yards receiving to three players this year.
• The Titans have allowed a touchdown catch by 23 players this season.
• Tennessee has given up at least two receiving touchdowns to just two players this season.
• The Titans have allowed just two players to pick up over 100 yards rushing in a game this season.
• A total of 16 players have run for at least one touchdown against Tennessee this year.
• The Titans have given up at least two rushing TDs to only two players this year.

Want more data and analysis on Patrick Mahomes? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.