Panthers vs Sabres NHL Prediction, Odds, Picks, Best Bets for Oct. 18

NHL action on Saturday includes the Florida Panthers facing the Buffalo Sabres.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NHL moneyline insights you need to know.

Panthers vs Sabres Game Info

• Florida Panthers (3-3) vs. Buffalo Sabres (1-3)
• Date: Saturday, October 18, 2025
• Time: 1 p.m. ET
• Venue: KeyBank Center -- Buffalo, New York
• Coverage: ESPN+

Panthers vs Sabres Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Panthers vs Sabres Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Panthers win (54.8%)

Panthers vs Sabres Puck Line

• The Sabres are 1.5-goal underdogs against the Panthers. The Sabres are -215 to cover the spread, and the Panthers are +172.

Panthers vs Sabres Over/Under

• Panthers versus Sabres on Oct. 18 has an over/under of 5.5 goals, with the over -138 and the under +112.

Panthers vs Sabres Moneyline

• The Panthers vs Sabres moneyline has Florida as a -144 favorite, while Buffalo is a +120 underdog at home.

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