Panthers vs Oilers NHL Prediction, Odds, Picks, Best Bets for Nov. 22

The Saturday slate in the NHL includes a matchup between the Florida Panthers and the Edmonton Oilers.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NHL moneyline insights you need to know.

Panthers vs Oilers Game Info

• Florida Panthers (11-8-1) vs. Edmonton Oilers (9-9-5)
• Date: Saturday, November 22, 2025
• Time: 7 p.m. ET
• Venue: Amerant Bank Arena -- Sunrise, Florida
• Coverage: NHL Network

Panthers vs Oilers Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Panthers vs Oilers Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Panthers win (65%)

Panthers vs Oilers Puck Line

• The Panthers are favored by 1.5 goals (+184 to cover). Edmonton, the underdog, is -230.

Panthers vs Oilers Over/Under

• The over/under for Panthers-Oilers on Nov. 22 is 5.5. The over is -132, and the under is +108.

Panthers vs Oilers Moneyline

• The moneyline numbers for Panthers vs. Oilers reveal Florida as the favorite (-130) and Edmonton as the underdog (+108) on the road.

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