Panthers vs Bruins NHL Prediction, Odds, Picks, Best Bets for Oct. 21

NHL action on Tuesday includes the Florida Panthers facing the Boston Bruins.

Before you place your bet on this game at FanDuel Sportsbook, here are the NHL moneyline insights you need to know.

Panthers vs Bruins Game Info

• Florida Panthers (3-4) vs. Boston Bruins (3-4)
• Date: Tuesday, October 21, 2025
• Time: 7:30 p.m. ET
• Venue: TD Garden -- Boston, Massachusetts
• Coverage: ESPN

Panthers vs Bruins Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Panthers vs Bruins Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Panthers win (65.2%)

Panthers vs Bruins Puck Line

• The Panthers are favored by 1.5 goals against the Bruins. The Panthers are +158 to cover the spread, while the Bruins are -196.

Panthers vs Bruins Over/Under

• A total of 5.5 goals has been set for the Panthers-Bruins game on Oct. 21, with the over available at -115 and the under at -105.

Panthers vs Bruins Moneyline

• Boston is the underdog, +126 on the moneyline, while Florida is a -152 favorite despite being on the road.

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