Panthers vs Blues NHL Prediction, Odds, Picks, Best Bets for Dec. 20

The Florida Panthers versus the St. Louis Blues is on the NHL schedule for Saturday.

Get the latest NHL odds ahead of this matchup on FanDuel Sportsbook.

Panthers vs Blues Game Info

• Florida Panthers (19-13-2) vs. St. Louis Blues (13-15-8)
• Date: Saturday, December 20, 2025
• Time: 6 p.m. ET
• Venue: Amerant Bank Arena -- Sunrise, Florida
• Coverage: ESPN+

Panthers vs Blues Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Panthers vs Blues Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Panthers win (60.9%)

Panthers vs Blues Puck Line

• The Blues are underdogs by 1.5 goals on the road against the Panthers. The Blues are -172 to cover the spread, and the Panthers are +140.

Panthers vs Blues Over/Under

• A total of 5.5 goals has been set for the Panthers-Blues matchup on Dec. 20, with the over available at -118 and the under at -104.

Panthers vs Blues Moneyline

• Florida is the favorite, -176 on the moneyline, while St. Louis is a +146 underdog on the road.

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