Padres vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 1

Odds updated as of 9:12 p.m.

The MLB's Friday schedule includes the San Diego Padres taking on the St. Louis Cardinals.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Cardinals Game Info

• San Diego Padres (60-49) vs. St. Louis Cardinals (55-55)
• Date: Friday, August 1, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSMW

Padres vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-205) | STL: (+172)
• Spread: SD: -1.5 (+106) | STL: +1.5 (-128)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Padres vs Cardinals Probable Starting Pitchers

Probable Pitchers: Nick Pivetta (Padres) - 10-3, 2.81 ERA vs Matthew Liberatore (Cardinals) - 6-8, 4.04 ERA

This contest's pitching matchup is set, as the Padres will send Nick Pivetta (10-3) to the mound, while Matthew Liberatore (6-8) will get the nod for the Cardinals. Pivetta and his team are 12-9-0 ATS this season when he starts. Pivetta's team has a record of 7-5 this season when he starts and they are the favorite on the moneyline. The Cardinals have gone 9-10-0 against the spread when Liberatore starts. The Cardinals have a 5-1 record in Liberatore's six starts this season when they were the underdog on the moneyline.

Padres vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (57.6%)

Padres vs Cardinals Moneyline

• San Diego is a -205 favorite on the moneyline, while St. Louis is a +172 underdog on the road.

Padres vs Cardinals Spread

• The Padres are hosting the Cardinals and are favored by 1.5 runs (+106 to cover) on the runline. St. Louis is -128 to cover.

Padres vs Cardinals Over/Under

• Padres versus Cardinals, on Aug. 1, has an over/under of 7.5, with the over being -110 and the under -110.

Bet on San Diego Padres vs. St. Louis Cardinals on FanDuel today!

Padres vs Cardinals Betting Trends

• The Padres have been chosen as favorites in 53 games this year and have walked away with the win 32 times (60.4%) in those games.
• This season San Diego has been victorious three times in six chances when named as a favorite of at least -205 on the moneyline.
• The Padres and their opponents have hit the over in 44 of their 107 games with a total set by oddsmakers this season.
• The Padres have an against the spread mark of 59-48-0 in 107 games with a line this season.
• The Cardinals have been the moneyline underdog 54 total times this season. They've finished 27-27 in those games.
• St. Louis has played as a moneyline underdog of +172 or longer in only one game this season, which it lost.
• In the 107 games bookmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 54 times (54-48-5).
• The Cardinals have covered 52.3% of their games this season, going 56-51-0 ATS.

Padres Player Leaders

• Manny Machado leads San Diego with 127 hits and a team-best slugging percentage of .510. He's batting .302 with an on-base percentage of .362.
• Among all qualifying hitters in MLB, he ranks seventh in batting average, 26th in on-base percentage, and 16th in slugging.
• Machado will look for his ninth straight game with a hit in this contest. During his last 10 outings he is hitting .429 with four doubles, two home runs and 11 RBIs.
• Fernando Tatis Jr. has 18 doubles, two triples, 17 home runs and 60 walks. He's batting .269 and slugging .449 with an on-base percentage of .369.
• His batting average is 55th among qualified players, his on-base percentage 20th, and his slugging percentage 64th.
• Tatis heads into this game looking to extend his four-game hit streak. In his last five games he is hitting .278 with two doubles, five walks and an RBI.
• Luis Arraez has collected 123 base hits, an OBP of .331 and a slugging percentage of .405 this season.
• Arraez has picked up a hit in 13 games in a row. During his last 10 outings he is hitting .400 with three doubles, a home run, three walks and five RBIs.
• Xander Bogaerts has seven home runs, 37 RBI and a batting average of .267 this season.

Cardinals Player Leaders

• Brendan Donovan has accumulated a .358 on-base percentage and a .416 slugging percentage, both team-high marks for the Cardinals. He's batting .285.
• Including all the qualified hitters in the majors, he ranks 24th in batting average, 33rd in on-base percentage and 88th in slugging percentage.
• Alec Burleson's 96 hits pace his team. He has a batting average of .287 while slugging .469 with an on-base percentage of .341.
• Including all qualifying hitters, he is 22nd in batting average, 57th in on-base percentage and 41st in slugging percentage.
• Willson Contreras is hitting .257 with 28 doubles, 14 home runs and 34 walks.
• Masyn Winn is hitting .270 with 23 doubles, seven home runs and 27 walks.

Padres vs Cardinals Head to Head

• 7/27/2025: 9-2 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/26/2025: 3-1 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/25/2025: 3-0 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 9-7 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/29/2024: 4-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/28/2024: 4-3 STL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/27/2024: 7-5 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/26/2024: 7-4 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/3/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 4/2/2024: 5-2 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)

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