Orioles vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 17

Odds updated as of 10:12 p.m.

On Wednesday in MLB, the Baltimore Orioles are up against the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Orioles vs White Sox Game Info

• Baltimore Orioles (70-80) vs. Chicago White Sox (57-94)
• Date: Wednesday, September 17, 2025
• Time: 2:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and MASN2

Orioles vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-118) | CHW: (-100)
• Spread: BAL: -1.5 (+138) | CHW: +1.5 (-166)
• Total: 8 -- Over: (-110) | Under: (-110)

Orioles vs White Sox Probable Starting Pitchers

Probable Pitchers: Tyler Wells (Orioles) - 1-0, 2.31 ERA vs Martín Pérez (White Sox) - 1-5, 3.27 ERA

This contest's pitching matchup is set, as the Orioles will send Tyler Wells (1-0) to the mound, while Martin Perez (1-5) will answer the bell for the White Sox. Wells has a record of 2-0-0 ATS in two starts with a spread this season. This will be Wells' first start this season with his team as the moneyline favorite. The White Sox have a 6-3-0 record against the spread in Pérez's starts. The White Sox have been the underdog on the moneyline in nine of Pérez's starts this season, and they went 3-6 in those games.

Orioles vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (51.4%)

Orioles vs White Sox Moneyline

• Looking at the moneyline for Orioles-White Sox, Baltimore is the favorite at -118, and Chicago is -100 playing at home.

Orioles vs White Sox Spread

• The Orioles are favored by 1.5 runs on the road against the White Sox. The Orioles are +138 to cover the spread, while the White Sox are -166.

Orioles vs White Sox Over/Under

• The over/under for the Orioles versus White Sox game on Sept. 17 has been set at 8, with -110 odds on the over and -110 odds on the under.

Bet on Baltimore Orioles vs. Chicago White Sox on FanDuel today!

Orioles vs White Sox Betting Trends

• The Orioles have won in 29, or 48.3%, of the 60 contests they have been named as odds-on favorites in this year.
• This year Baltimore has won 26 of 51 games when listed as at least -118 on the moneyline.
• Contests with the Orioles have gone over the total set by oddsmakers in 62 of 147 chances this season.
• The Orioles are 71-76-0 against the spread in their 147 games with a line set by sportsbooks this season.
• The White Sox have been the moneyline underdog 143 total times this season. They've finished 53-90 in those games.
• Chicago has gone 51-86 when it has played as a moneyline underdog with odds of -100 or longer (37.2%).
• The White Sox have played in 146 games with an over/under set, and have combined with their opponents to go over the total 67 times (67-71-8).
• The White Sox have covered 56.8% of their games this season, going 83-63-0 ATS.

Orioles Player Leaders

• Gunnar Henderson has 143 hits and an OBP of .346 to go with a slugging percentage of .439. All three of those stats are tops among Baltimore hitters this season. He has a .269 batting average, as well.
• Among all qualified hitters in MLB, he is 40th in batting average, 42nd in on-base percentage, and 66th in slugging.
• Jackson Holliday has 21 doubles, three triples, 17 home runs and 52 walks. He's batting .255 and slugging .396 with an on-base percentage of .325.
• Among all qualifying hitters, he ranks 81st in batting average, 83rd in on-base percentage and 106th in slugging percentage.
• Holliday brings an eight-game streak with at least one hit into this matchup. During his last 10 games he is batting .371 with a double, two home runs, eight walks and four RBIs.
• Jordan Westburg is batting .276 with a .473 slugging percentage and 34 RBI this year.
• Colton Cowser is batting .202 with a .271 OBP and 38 RBI for Baltimore this season.
• Cowser has hit safely in two games in a row. During his last five outings he is hitting .118 with two home runs, two walks and four RBIs.

White Sox Player Leaders

• Miguel Vargas has put up an on-base percentage of .312, a team-high for the White Sox. He's batting .231 and slugging .397.
• Including all the qualified hitters in MLB, he ranks 129th in batting average, 109th in on-base percentage and 105th in slugging percentage.
• Andrew Benintendi is batting .240 with 16 doubles, two triples, 19 home runs and 38 walks. He's slugging .424 with an on-base percentage of .304.
• Lenyn Sosa has racked up a slugging percentage of .426 and has 126 hits, both team-high numbers for the White Sox.
• Chase Meidroth is batting .270 with 15 doubles, five home runs and 43 walks.

Orioles vs White Sox Head to Head

• 9/15/2025: 4-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/1/2025: 3-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/31/2025: 4-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/30/2025: 2-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/4/2024: 8-1 CHW (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 9/3/2024: 9-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -320, Underdog Moneyline: +260)
• 9/2/2024: 13-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -460, Underdog Moneyline: +360)
• 5/25/2024: 5-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/24/2024: 6-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 5/23/2024: 8-6 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -240, Underdog Moneyline: +194)

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