Oklahoma vs Michigan Prediction, Odds, Picks, Best Bets for Week 2 2025

NCAA football action on Saturday includes the Oklahoma Sooners facing the Michigan Wolverines.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Oklahoma vs Michigan Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Oklahoma: (-205) | Michigan: (+168)
• Spread: Oklahoma: -5.5 (-110) | Michigan: +5.5 (-110)
• Total: 44.5 -- Over: (-105) | Under: (-115)

Oklahoma vs Michigan Betting Trends

• Oklahoma has no wins against the spread this season.
• Oklahoma is winless ATS (0-1) as a 5.5-point favorite or greater this year.
• Michigan has not won a game against the spread this year.
• Every Michigan game has hit the over this season.

Oklahoma vs Michigan Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Sooners win (58.4%)

Oklahoma vs Michigan Point Spread

Michigan is the underdog by 5.5 points against Oklahoma. Michigan is -110 to cover the spread, and Oklahoma is -110.

Oklahoma vs Michigan Over/Under

A combined point total of 44.5 has been set for Oklahoma-Michigan on Sept. 6, with the over at -105 and the under at -115.

Oklahoma vs Michigan Moneyline

Oklahoma is the favorite, -205 on the moneyline, while Michigan is a +168 underdog.

Oklahoma vs. Michigan Points Insights

• The Sooners' average implied point total last season was 6.2 more points than their implied total in Saturday's game (31.2 implied points on average compared to 25 implied points in this game).
• The Wolverines' average implied point total last season (26.9 points) is 6.9 points higher than their implied total in this matchup (20 points).

Oklahoma vs. Michigan Game Info

• Game day: Saturday, September 6, 2025
• Game time: 7:30 p.m. ET
• TV channel: ABC
• Location: Norman, Oklahoma
• Stadium: Gaylord Family Oklahoma Memorial Stadium

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Check out even more in-depth Oklahoma vs. Michigan analysis on FanDuel Research.