Oilers vs Senators NHL Prediction, Odds, Picks, Best Bets for Oct. 21

The Edmonton Oilers are among the NHL squads in action on Tuesday, up against the Ottawa Senators.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NHL betting insights.

Oilers vs Senators Game Info

• Edmonton Oilers (2-3-1) vs. Ottawa Senators (2-4)
• Date: Tuesday, October 21, 2025
• Time: 7 p.m. ET
• Venue: Canadian Tire Centre -- Ottawa, Ontario
• Coverage: ESPN+

Oilers vs Senators Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Oilers vs Senators Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Senators win (51.9%)

Oilers vs Senators Puck Line

• The Senators are underdogs by 1.5 goals. The Senators are -225 to cover the spread, and the Oilers are +180.

Oilers vs Senators Over/Under

• The over/under for Oilers-Senators on Oct. 21 is 6.5. The over is +114, and the under is -140.

Oilers vs Senators Moneyline

• Ottawa is a +112 underdog on the moneyline, while Edmonton is a -134 favorite on the road.

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