Ohio vs Buffalo Prediction, Odds, Picks, Best Bets for Week 14 2025

The Friday slate in college football includes a matchup between the Ohio Bobcats and the Buffalo Bulls.

We've got you covered, in terms of the most important information regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Ohio vs Buffalo Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ohio: (-270) | Buffalo: (+220)
• Spread: Ohio: -6.5 (-124) | Buffalo: +6.5 (102)
• Total: 44.5 -- Over: (-115) | Under: (-105)

Ohio vs Buffalo Betting Trends

• Ohio's record against the spread is 6-5-0.
• As at least a 6.5-point favorite, Ohio has two wins ATS (2-4).
• There have been five Ohio games (of 11) that went over the total this year.
• Buffalo's record against the spread in 2025 is 4-7-0.
• Buffalo is unbeaten ATS (1-0) as a 6.5-point underdog or greater this season.
• Of 11 Buffalo games so far this season, six have hit the over.

Ohio vs Buffalo Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Bobcats win (72.8%)

Ohio vs Buffalo Point Spread

Buffalo is listed as an underdog by 6.5 points (+102 odds), and Ohio, the favorite, is -124 to cover.

Ohio vs Buffalo Over/Under

An over/under of 44.5 has been set for Ohio-Buffalo on Nov. 28, with the over being -115 and the under -105.

Ohio vs Buffalo Moneyline

Ohio is the favorite, -270 on the moneyline, while Buffalo is a +220 underdog.

Ohio vs. Buffalo Points Insights

Ohio vs. Buffalo Game Info

• Game day: Friday, November 28, 2025
• Game time: 12 p.m. ET
• TV channel: ESPNU
• Location: Buffalo, New York
• Stadium: UB Stadium

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Check out even more in-depth Ohio vs. Buffalo analysis on FanDuel Research.