Ohio State vs Indiana Prediction, Odds, Picks, Best Bets for Big Ten Championship Game 2025

In college football action on Saturday, the Ohio State Buckeyes take on the Indiana Hoosiers.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Ohio State vs Indiana Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ohio State: (-180) | Indiana: (+152)
• Spread: Ohio State: -4.5 (-105) | Indiana: +4.5 (-115)
• Total: 46.5 -- Over: (-114) | Under: (-106)

Ohio State vs Indiana Betting Trends

• Ohio State is 10-2-0 against the spread this season.
• On the season, Ohio State is 9-2 as 4.5-point or better favorites.
• This season, four of Ohio State's 12 games have hit the over.
• Indiana is 7-5-0 against the spread this year.
• Indiana has covered every time (1-0) as a 4.5-point or greater underdog this season.
• Indiana has played 12 games this season, and eight of them have gone over the total.

Ohio State vs Indiana Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Buckeyes win (58%)

Ohio State vs Indiana Point Spread

Ohio State is favored by 4.5 points over Indiana. Ohio State is -105 to cover the spread, with Indiana being -115.

Ohio State vs Indiana Over/Under

The over/under for the Ohio State versus Indiana matchup on Dec. 6 has been set at 46.5, with -114 odds on the over and -106 odds on the under.

Ohio State vs Indiana Moneyline

Indiana is a +152 underdog on the moneyline, while Ohio State is a -180 favorite.

Ohio State vs. Indiana Points Insights

Ohio State vs. Indiana Game Info

• Game day: Saturday, December 6, 2025
• Game time: 8 p.m. ET
• TV channel: FOX
• Location: Indianapolis, Indiana
• Stadium: Lucas Oil Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Ohio State vs. Indiana analysis on FanDuel Research.