North Carolina vs Notre Dame College Basketball Prediction, Odds, Picks, Best Bets for Jan. 21

The North Carolina Tar Heels (14-4, 2-3 ACC) aim to extend a 12-game home winning streak when they host the Notre Dame Fighting Irish (10-8, 1-4 ACC) on January 21, 2026.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

North Carolina vs. Notre Dame Game Info and Odds

• Game day: Wednesday, January 21, 2026
• Game time: 7 p.m. ET
• TV channel: ESPN2
• Location: Chapel Hill, North Carolina
• Arena: Dean E. Smith Center

Before you wager on Wednesday's North Carolina-Notre Dame spread (North Carolina -13.5) or total (149.5 points), read the betting trends and insights below.

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North Carolina vs. Notre Dame: ATS Betting Stats and Trends

• North Carolina has covered eight times in 18 matchups with a spread this season.
• Notre Dame has put together a 9-8-0 record against the spread this season.
• Against the spread, the Tar Heels have fared better when playing at home, covering six times in 11 home games, and one time in four road games.
• The Fighting Irish's winning percentage against the spread at home is .444 (4-5-0). On the road, it is .800 (4-1-0).
• North Carolina has no wins against the spread in conference action this year.
• Notre Dame has won twice against the spread in ACC action this season.

North Carolina vs. Notre Dame: Moneyline Betting Stats

• North Carolina has been the moneyline favorite in 14 games this season and has come away with the win 12 times (85.7%) in those contests.
• The Tar Heels have yet to lose in six games when named as moneyline favorite of -1250 or better.
• Notre Dame has won 30% of the games this season it was the moneyline underdog (3-7).
• The Fighting Irish have yet to play as a moneyline underdog of +740 or longer.
• Oddsmakers have implied with the moneyline set for this matchup that North Carolina has a 92.6% chance of pulling out a win.

North Carolina vs. Notre Dame Head-to-Head Comparison

• North Carolina put up 80.7 points per game and allowed 74.7 last year, ranking them 29th in college basketball offensively and 261st defensively.
• With 33.2 rebounds per game and 31.2 rebounds allowed, North Carolina was 105th and 182nd in the country, respectively, last year.
• Last season North Carolina was ranked 93rd in the country in assists with 14.7 per game.
• North Carolina was 120th in the nation in turnovers per game (10.5) and 288th in turnovers forced (10.2) last season.
• On offense, Notre Dame put up 72.6 points per game (212th-ranked in college basketball) last year. It gave up 72.5 points per contest at the other end (195th-ranked).
• Last year Notre Dame pulled down 31.6 boards per game (194th-ranked in college basketball) and gave up 29.1 rebounds per contest (56th-ranked).
• Last season Notre Dame ranked 323rd in college basketball in assists, averaging 11.4 per game.
• Notre Dame ranked 98th in the country at 10.3 turnovers per contest, but it forced 9.5 turnovers per game, which ranked 25th-worst in college basketball.

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