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San Francisco 49ers Vs. Arizona Cardinals Odds, Betting Lines, Score & Stats (November 16, 2025) | FanDuel Research

FanDuel Research>
NFL>
Matchups>
San Francisco 49ers Vs. Arizona Cardinals

FOX

San Francisco 49ers

6-4 | 3rd in NFC West | 8th in NFC

SpreadMoneylineTotal

@

Arizona Cardinals

3-6 | 4th in NFC West | 12th in NFC

SpreadMoneylineTotal

FOX

State Farm Stadium

Featured Player Props

View all NFL Player Props

Odds not available yet.

Check back closer to game time!

Type

Passing Yards

Receiving Yards

Rushing Yards

Passing Touchdowns

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Line Movement

These graphs show how the spread, moneyline, and total have shifted at FanDuel Sportsbook over time.

Spread

49ers

Open: -1.5

Cardinals

Open: +1.5

Moneyline

49ers

Open: -116

Cardinals

Open: -102

Total

Over

Open: 47.5

Under

Open: 47.5

Featured Promos

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Popular Bets

Odds not available yet.

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4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

Top Projected Fantasy Performers

Injuries

Team Stats

View all Team Stats

Game Log

More NFL Games

NFL $2M Touchdown Jackpot

NBA Parlay/SGP Profit Boost

Community Play of The Day TNF SGP

NFL Profit Boost

San Francisco 49ers

RBChristian McCaffrey

20.9 Points

18.7 Points

WRJauan Jennings

10.1 Points

TEGeorge Kittle

9.8 Points

Arizona Cardinals

QBJacoby Brissett

16.2 Points

14.6 Points

WRMichael Wilson

9.1 Points

6.7 Points

SF

ARI

6.192

Offensive EPA

2.7912

11.696

Passing EPA

4.1868

0

Rushing EPA

0.6978

10.32

Defensive EPA

6.2802

13.76

Def Pass EPA

7.6758

5.504

Def Rush EPA

3.489

NFL

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San Francisco 49ers

NameStatus

WRTrent Taylor

IRUndisclosed

LBFred Warner

IRAnkle

RBPatrick Taylor Jr.

IRShoulder

DLNick Bosa

IRKnee - ACL

QBBrock Purdy

QToe

DLYetur Gross-Matos

IRKnee

Arizona Cardinals

NameStatus

RBJames Conner

IRFoot

WRZay Jones

IRAchilles

DLL.J. Collier

IRKnee

DLJustin Jones

IRKnee

QBKyler Murray

IRFoot

OLJonah Williams

QShoulder

San Francisco 49ers

DateOpponentResultSpread

vs

LARL 42 - 26+3.5

@

NYGW 34 - 24-2.5

@

HOUL 15 - 26-1.5

vs

ATLW 10 - 20-3

@

TBL 19 - 30+3

@

LARW 26 - 23+5.5

Arizona Cardinals

DateOpponentResultSpread

@

SEAL 22 - 44+6.5

@

DALW 27 - 17+3.5

vs

GBL 27 - 23+6.5

@

INDL 27 - 31+6.5

vs

TENL 22 - 21-8.5

vs

SEAL 23 - 20-1.5