NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 4

The Week 4 NFL schedule has plenty of exciting matchups in store. Among those contests is the Baltimore Ravens playing the Kansas City Chiefs.

If you're looking for additional betting intel for Week 4 in the NFL, we have you covered with odds for all the important games.

Cardinals vs. Seahawks

The Seattle Seahawks (2-1), who rank fifth in the league by scoring 29.3 points per game, will be tested by the fifth-ranked scoring defense of the Arizona Cardinals (2-1), who allow opponents to score 17 per game. The game begins at 8:15 p.m. ET on Thursday, Sept. 25 at State Farm Stadium.

• Game Preview: Seattle Seahawks at Arizona Cardinals
• Projected Favorite: Cardinals (55.65% win probability)
• Spread: Seattle (-1.5)
• Total: 43.5 -- Over: (-110) | Under: (-110)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Arizona vs. Seattle with FanDuel Sportsbook.

Steelers vs. Vikings

On Sunday at 9:30 a.m. ET, the Minnesota Vikings (2-1) will take on the Pittsburgh Steelers (2-1).

• Game Preview: Minnesota Vikings vs. Pittsburgh Steelers
• Projected Favorite: Vikings (57.56% win probability)
• Spread: Minnesota (-2.5)
• Total: 40.5 -- Over: (-112) | Under: (-108)
• Time: 9:30 a.m. ET
• Channel: NFL Network

Bet on Pittsburgh vs. Minnesota with FanDuel Sportsbook.

Texans vs. Titans

The Tennessee Titans (0-3) will visit the Houston Texans (0-3) on Sunday at 1 p.m. ET.

• Game Preview: Tennessee Titans at Houston Texans
• Projected Favorite: Texans (79.89% win probability)
• Spread: Houston (-7.5)
• Total: 39.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Houston vs. Tennessee with FanDuel Sportsbook.

Lions vs. Browns

The 1 p.m. ET tilt on Sept. 28 between the Detroit Lions (2-1) and the Cleveland Browns (1-2) should be a competitive matchup, as Amon-Ra St. Brown has been one of the NFL's top receivers this year, and the Browns have been a top-five pass defense, ranking fourth-best in the NFL at 147.0 passing yards allowed per game.

• Game Preview: Cleveland Browns at Detroit Lions
• Projected Favorite: Lions (86.63% win probability)
• Spread: Detroit (-9.5)
• Total: 44.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Detroit vs. Cleveland with FanDuel Sportsbook.

Falcons vs. Commanders

The Atlanta Falcons (1-2) are scheduled to collide with the Washington Commanders (2-1) at Mercedes-Benz Stadium on Sunday, Sept. 28 at 1 p.m. ET. In their last contests, the Falcons were defeated by the Panthers 30-0, and the Commanders won 41-24 against the Raiders.

• Game Preview: Washington Commanders at Atlanta Falcons
• Projected Favorite: Commanders (59.20% win probability)
• Spread: Atlanta (-2.5)
• Total: 43.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Atlanta vs. Washington with FanDuel Sportsbook.

Giants vs. Chargers

The New York Giants (0-3) and their 28th-ranked pass defense might have difficulty stopping the Los Angeles Chargers (3-0) and Justin Herbert, one of the league's top passers, when the Giants host the Chargers at MetLife Stadium on Sept. 28 at 1 p.m. ET.

• Game Preview: Los Angeles Chargers at New York Giants
• Projected Favorite: Chargers (75.94% win probability)
• Spread: Los Angeles (-6.5)
• Total: 43.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Los Angeles with FanDuel Sportsbook.

Buccaneers vs. Eagles

At Raymond James Stadium on Sunday, Jalen Hurts and the Philadelphia Eagles (3-0) play Emeka Egbuka and the Tampa Bay Buccaneers (3-0) in a battle featuring two of the biggest stars in football, starting at 1 p.m. ET.

• Game Preview: Philadelphia Eagles at Tampa Bay Buccaneers
• Projected Favorite: Buccaneers (56.11% win probability)
• Spread: Philadelphia (-3.5)
• Total: 44.5 -- Over: (-102) | Under: (-120)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Tampa Bay vs. Philadelphia with FanDuel Sportsbook.

Patriots vs. Panthers

Hunter Henry and the New England Patriots (1-2) play the Carolina Panthers (1-2) on Sunday at 1 p.m. ET, at Gillette Stadium.

• Game Preview: Carolina Panthers at New England Patriots
• Projected Favorite: Patriots (67.03% win probability)
• Spread: New England (-5.5)
• Total: 43.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New England vs. Carolina with FanDuel Sportsbook.

Bills vs. Saints

The team with the NFL's fourth-ranked scoring offense, the Buffalo Bills (3-0), host the New Orleans Saints (0-3) and their 29th-ranked scoring offense on Sunday, Sept. 28 at 1 p.m. ET. The Bills produce 34.0 points per game, while the Saints average 15.7.

• Game Preview: New Orleans Saints at Buffalo Bills
• Projected Favorite: Bills (86.78% win probability)
• Spread: Buffalo (-14.5)
• Total: 48.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Buffalo vs. New Orleans with FanDuel Sportsbook.

Rams vs. Colts

At SoFi Stadium on Sunday, Puka Nacua and the Los Angeles Rams (2-1) meet Daniel Jones and the Indianapolis Colts (3-0) in a battle featuring two of the brightest stars in football, starting at 4:05 p.m. ET.

• Game Preview: Indianapolis Colts at Los Angeles Rams
• Projected Favorite: Rams (56.09% win probability)
• Spread: Los Angeles (-3.5)
• Total: 49.5 -- Over: (-112) | Under: (-108)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on Los Angeles vs. Indianapolis with FanDuel Sportsbook.

49ers vs. Jaguars

Two excellent running backs will be on display when Christian McCaffrey and the San Francisco 49ers (3-0) host Travis Etienne and the Jacksonville Jaguars (2-1) on Sunday, September 28, 2025.

• Game Preview: Jacksonville Jaguars at San Francisco 49ers
• Projected Favorite: 49ers (55.89% win probability)
• Spread: San Francisco (-3.5)
• Total: 46.5 -- Over: (-105) | Under: (-115)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on San Francisco vs. Jacksonville with FanDuel Sportsbook.

Raiders vs. Bears

After going down 41-24 to the Commanders in their last game, the Las Vegas Raiders (1-2) will host the Chicago Bears (1-2), who are coming off a 31-14 victory over the Cowboys. Kickoff is scheduled for 4:25 p.m. ET on Sunday, Sept. 28.

• Game Preview: Chicago Bears at Las Vegas Raiders
• Projected Favorite: Raiders (50.54% win probability)
• Spread: Las Vegas (-1.5)
• Total: 47.5 -- Over: (-118) | Under: (-104)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Las Vegas vs. Chicago with FanDuel Sportsbook.

Chiefs vs. Ravens

Two of the best offensive performers in football will be featured when quarterback Lamar Jackson and the Baltimore Ravens (1-2) visit running back Patrick Mahomes and the Kansas City Chiefs (1-2) on Sunday, September 28, 2025.

• Game Preview: Baltimore Ravens at Kansas City Chiefs
• Projected Favorite: Ravens (62.17% win probability)
• Spread: Baltimore (-2.5)
• Total: 48.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Kansas City vs. Baltimore with FanDuel Sportsbook.

Cowboys vs. Packers

The Green Bay Packers (2-1) and the Dallas Cowboys (1-2), who were both defeated in their last game, will go head to head at 8:20 p.m. ET on Sunday, Sept. 28. In their previous games, the Packers lost 13-10 to the Browns, and the Cowboys were taken down by the Bears 31-14.

• Game Preview: Green Bay Packers at Dallas Cowboys
• Projected Favorite: Packers (74.35% win probability)
• Spread: Green Bay (-6.5)
• Total: 46.5 -- Over: (-110) | Under: (-110)
• Time: 8:20 p.m. ET
• Channel: NBC

Bet on Dallas vs. Green Bay with FanDuel Sportsbook.

Dolphins vs. Jets

The Miami Dolphins (0-3) and the New York Jets (0-3), who both lost their last game, will play at 7:15 p.m. ET on Monday, Sept. 29. In their previous games, the Dolphins lost 31-21 to the Bills, and the Jets were taken down by the Buccaneers 29-27.

• Game Preview: New York Jets at Miami Dolphins
• Projected Favorite: Dolphins (63.74% win probability)
• Spread: Miami (-2.5)
• Total: 44.5 -- Over: (-108) | Under: (-112)
• Time: 7:15 p.m. ET
• Channel: ESPN

Bet on Miami vs. New York with FanDuel Sportsbook.

Broncos vs. Bengals

The Denver Broncos (1-2), who lost to the Chargers in their previous tilt, host the Cincinnati Bengals (2-1) at Empower Field at Mile High on Sept. 29 at 8:15 p.m. ET. The Bengals lost to the Vikings in their last game.

• Game Preview: Cincinnati Bengals at Denver Broncos
• Projected Favorite: Broncos (75.93% win probability)
• Spread: Denver (-7.5)
• Total: 44.5 -- Over: (-105) | Under: (-115)
• Time: 8:15 p.m. ET
• Channel: ABC

Bet on Denver vs. Cincinnati with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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