NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 18

The Week 18 NFL lineup has several top-tier games, including a matchup between the Seattle Seahawks and the San Francisco 49ers.

Here's everything you need to know in terms of the betting odds for Week 18 in the NFL.

Buccaneers vs. Panthers

The Tampa Bay Buccaneers (7-9), who lost to the Dolphins in their last game, host the Carolina Panthers (8-8) at Raymond James Stadium on Jan. 3 at 4:30 p.m. ET. The Panthers took the L against the Seahawks in their last game.

• Game Preview: Carolina Panthers at Tampa Bay Buccaneers
• Projected Favorite: Buccaneers (52.56% win probability)
• Spread: Tampa Bay (-3)
• Total: 43.5 -- Over: (-110) | Under: (-110)
• Time: 4:30 p.m. ET
• Channel: ABC/ESPN

Bet on Tampa Bay vs. Carolina with FanDuel Sportsbook.

49ers vs. Seahawks

Christian McCaffrey, who ranks eighth-best in the league in rushing yards, will aim to lead the way for the San Francisco 49ers (12-4) on Jan. 3 at 8 p.m. ET, when they host the Seattle Seahawks (13-3) and their third-best run defense (94.4 rushing yards allowed per game).

• Game Preview: Seattle Seahawks at San Francisco 49ers
• Projected Favorite: 49ers (60.04% win probability)
• Spread: Seattle (-1.5)
• Total: 47.5 -- Over: (-118) | Under: (-104)
• Time: 8 p.m. ET
• Channel: ABC/ESPN

Bet on San Francisco vs. Seattle with FanDuel Sportsbook.

Vikings vs. Packers

When the Minnesota Vikings (8-8) and the Green Bay Packers (9-6-1) meet on Sunday, Jan. 4 at 1 p.m. ET, the Vikings will be looking to follow up their recent victory over the Lions with another win, and the Packers will be trying to rebound from a loss to the Ravens.

• Game Preview: Green Bay Packers at Minnesota Vikings
• Projected Favorite: Vikings (56.96% win probability)
• Spread: Minnesota (-7.5)
• Total: 35.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Minnesota vs. Green Bay with FanDuel Sportsbook.

Jaguars vs. Titans

Star quarterback Trevor Lawrence and the Jacksonville Jaguars (12-4) meet the Tennessee Titans (3-13) on Sunday at 1 p.m. ET at EverBank Stadium.

• Game Preview: Tennessee Titans at Jacksonville Jaguars
• Projected Favorite: Jaguars (87.34% win probability)
• Spread: Jacksonville (-12.5)
• Total: 47.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Jacksonville vs. Tennessee with FanDuel Sportsbook.

Falcons vs. Saints

The Atlanta Falcons (7-9) are scheduled to take on the New Orleans Saints (6-10) at Mercedes-Benz Stadium on Sunday, Jan. 4 at 1 p.m. ET. Both squads won their last contest, as the Falcons defeated the Rams 27-24, and the Saints won 34-26 against the Titans.

• Game Preview: New Orleans Saints at Atlanta Falcons
• Projected Favorite: Falcons (56.13% win probability)
• Spread: Atlanta (-3)
• Total: 44.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Atlanta vs. New Orleans with FanDuel Sportsbook.

Bengals vs. Browns

Ja'Marr Chase and the Cincinnati Bengals (6-10) will get a stiff test when they go toe to toe with the Cleveland Browns (4-12), who have the NFL's second-best pass defense, on Sunday, Jan. 4 at 1 p.m. ET. Chase is fourth-best in the league in receiving yards.

• Game Preview: Cleveland Browns at Cincinnati Bengals
• Projected Favorite: Bengals (68.94% win probability)
• Spread: Cincinnati (-7.5)
• Total: 44.5 -- Over: (-108) | Under: (-112)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Cincinnati vs. Cleveland with FanDuel Sportsbook.

Giants vs. Cowboys

Star quarterback Dak Prescott and the Dallas Cowboys (7-8-1) meet the New York Giants (3-13) on Sunday at 1 p.m. ET at MetLife Stadium.

• Game Preview: Dallas Cowboys at New York Giants
• Projected Favorite: Cowboys (59.84% win probability)
• Spread: Dallas (-3.5)
• Total: 49.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New York vs. Dallas with FanDuel Sportsbook.

Texans vs. Colts

The Indianapolis Colts (8-8) and their 31st-ranked pass defense might struggle to slow down the Houston Texans (11-5) and Nico Collins, one of the league's top pass-catchers, when the Colts visit the Texans at NRG Stadium on Jan. 4 at 1 p.m. ET.

• Game Preview: Indianapolis Colts at Houston Texans
• Projected Favorite: Texans (71.92% win probability)
• Spread: Houston (-10.5)
• Total: 38.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Houston vs. Indianapolis with FanDuel Sportsbook.

Patriots vs. Dolphins

On Sunday at 4:25 p.m. ET, two of the top offensive performers in football will be featured when QB Drake Maye and the New England Patriots (13-3) host running back De'Von Achane and the Miami Dolphins (7-9).

• Game Preview: Miami Dolphins at New England Patriots
• Projected Favorite: Patriots (79.20% win probability)
• Spread: New England (-10.5)
• Total: 45.5 -- Over: (-105) | Under: (-115)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on New England vs. Miami with FanDuel Sportsbook.

Rams vs. Cardinals

On Sunday at 4:25 p.m. ET, two of the best offensive performers in football will be featured when QB Matthew Stafford and the Los Angeles Rams (11-5) host pass-catcher Trey McBride and the Arizona Cardinals (3-13).

• Game Preview: Arizona Cardinals at Los Angeles Rams
• Projected Favorite: Rams (84.50% win probability)
• Spread: Los Angeles (-7.5)
• Total: 45.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Los Angeles vs. Arizona with FanDuel Sportsbook.

Raiders vs. Chiefs

One of the best pass-catchers in football will be on show when Travis Kelce and the Kansas City Chiefs (6-10) visit the Las Vegas Raiders (2-14) on Sunday, January 4, 2026.

• Game Preview: Kansas City Chiefs at Las Vegas Raiders
• Projected Favorite: Chiefs (64.35% win probability)
• Spread: Kansas City (-5.5)
• Total: 36.5 -- Over: (-106) | Under: (-114)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Las Vegas vs. Kansas City with FanDuel Sportsbook.

Eagles vs. Commanders

Against the Washington Commanders (4-12), who own the 31st-ranked run defense this season, Saquon Barkley and the Philadelphia Eagles (11-5) shouldn't have any trouble running the ball when the two teams meet on Sunday, Jan. 4 at 4:25 p.m. ET. Barkley has been one of the NFL's top rushers this year, ranking 10th-best in the league in rushing yards.

• Game Preview: Washington Commanders at Philadelphia Eagles
• Projected Favorite: Eagles (70.50% win probability)
• Spread: Philadelphia (-3.5)
• Total: 39.5 -- Over: (-105) | Under: (-115)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Philadelphia vs. Washington with FanDuel Sportsbook.

Broncos vs. Chargers

On Sunday at 4:25 p.m. ET, the Los Angeles Chargers (11-5) will visit the Denver Broncos (13-3).

• Game Preview: Los Angeles Chargers at Denver Broncos
• Projected Favorite: Broncos (76.03% win probability)
• Spread: Denver (-12.5)
• Total: 37.5 -- Over: (-112) | Under: (-108)
• Time: 4:25 p.m. ET

Bet on Denver vs. Los Angeles with FanDuel Sportsbook.

Bills vs. Jets

After losing 13-12 to the Eagles in their last game, the Buffalo Bills (11-5) will host the New York Jets (3-13), who are coming off a 42-10 loss to the Patriots, at Highmark Stadium. The game is slated for 4:25 p.m. ET on Sunday, Jan. 4.

• Game Preview: New York Jets at Buffalo Bills
• Projected Favorite: Bills (86.49% win probability)
• Spread: Buffalo (-7)
• Total: 38.5 -- Over: (-105) | Under: (-115)
• Time: 4:25 p.m. ET

Bet on Buffalo vs. New York with FanDuel Sportsbook.

Bears vs. Lions

Star running back Jahmyr Gibbs and the Detroit Lions (8-8) meet the Chicago Bears (11-5) on Sunday at 4:25 p.m. ET, at Soldier Field.

• Game Preview: Detroit Lions at Chicago Bears
• Projected Favorite: Bears (62.81% win probability)
• Spread: Chicago (-3)
• Total: 50.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Chicago vs. Detroit with FanDuel Sportsbook.

Steelers vs. Ravens

Against the Pittsburgh Steelers (9-7), who own the 29th-ranked pass defense this season, Zay Flowers and the Baltimore Ravens (8-8) should have success through the air when the two teams match up on Sunday, Jan. 4 at 8:20 p.m. ET. Flowers has been one of the NFL's top receivers this season, ranking ninth-best in the league in receiving yards.

• Game Preview: Baltimore Ravens at Pittsburgh Steelers
• Projected Favorite: Ravens (59.45% win probability)
• Spread: Baltimore (-3.5)
• Total: 41.5 -- Over: (-105) | Under: (-115)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Pittsburgh vs. Baltimore with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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