NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 17

The Week 17 NFL slate features several top-tier games, including a matchup between the Jacksonville Jaguars and the Indianapolis Colts.

With Week 17 in the NFL upon us, stay on top of the most current betting trends with our preview below.

Commanders vs. Cowboys

The Washington Commanders (4-11) and their 29th-ranked run defense could have difficulty stopping the Dallas Cowboys (6-8-1) and Javonte Williams, one of the NFL's top rushers, when the Commanders host the Cowboys at Northwest Stadium on Dec. 25 at 1 p.m. ET.

• Game Preview: Dallas Cowboys at Washington Commanders
• Projected Favorite: Cowboys (58.51% win probability)
• Spread: Dallas (-7)
• Total: 50.5 -- Over: (-106) | Under: (-114)
• Time: 1 p.m. ET
• Channel: Netflix

Bet on Washington vs. Dallas with FanDuel Sportsbook.

Vikings vs. Lions

The 4:30 p.m. ET contest on Dec. 25 between the Detroit Lions (8-7) and the Minnesota Vikings (7-8) should be an exciting matchup, as Amon-Ra St. Brown has been one of the NFL's top pass-catchers this year, and the Vikings have been a top-five pass defense, ranking third-best in the NFL at 169.2 passing yards allowed per contest.

• Game Preview: Detroit Lions at Minnesota Vikings
• Projected Favorite: Lions (67.21% win probability)
• Spread: Detroit (-7)
• Total: 43.5 -- Over: (-105) | Under: (-115)
• Time: 4:30 p.m. ET
• Channel: Netflix

Bet on Minnesota vs. Detroit with FanDuel Sportsbook.

Chiefs vs. Broncos

The Denver Broncos (12-3) and the Kansas City Chiefs (6-9), who both lost their last game, will go head to head at 8:15 p.m. ET on Thursday, Dec. 25. In their previous games, the Broncos lost 34-20 to the Jaguars, and the Chiefs were taken down by the Titans 26-9.

• Game Preview: Denver Broncos at Kansas City Chiefs
• Projected Favorite: Broncos (76.36% win probability)
• Spread: Denver (-12.5)
• Total: 36.5 -- Over: (-110) | Under: (-110)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Kansas City vs. Denver with FanDuel Sportsbook.

Chargers vs. Texans

After clinching a 34-17 victory against the Cowboys in their previous contest, the Los Angeles Chargers (11-4) will host the Houston Texans (10-5), who are coming off a 23-21 win over the Raiders, at SoFi Stadium. Kickoff is scheduled for 4:30 p.m. ET on Saturday, Dec. 27.

• Game Preview: Houston Texans at Los Angeles Chargers
• Projected Favorite: Chargers (58.42% win probability)
• Spread: Los Angeles (-1.5)
• Total: 39.5 -- Over: (-114) | Under: (-106)
• Time: 4:30 p.m. ET
• Channel: NFL Network

Bet on Los Angeles vs. Houston with FanDuel Sportsbook.

Packers vs. Ravens

Derrick Henry will lead the Baltimore Ravens (7-8) into their matchup against the Green Bay Packers (9-5-1) at Lambeau Field, on Saturday at 8 p.m. ET.

• Game Preview: Baltimore Ravens at Green Bay Packers
• Projected Favorite: Packers (61.54% win probability)
• Spread: Green Bay (-2.5)
• Total: 41.5 -- Over: (-104) | Under: (-118)
• Time: 8 p.m. ET
• Channel: Peacock

Bet on Green Bay vs. Baltimore with FanDuel Sportsbook.

Colts vs. Jaguars

The Jacksonville Jaguars (11-4) visit the Indianapolis Colts (8-7) on Sunday at 1 p.m. ET, in a battle featuring two of the best offensive players in football in QB Trevor Lawrence and running back Jonathan Taylor.

• Game Preview: Jacksonville Jaguars at Indianapolis Colts
• Projected Favorite: Jaguars (63.62% win probability)
• Spread: Jacksonville (-6.5)
• Total: 48.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Indianapolis vs. Jacksonville with FanDuel Sportsbook.

Dolphins vs. Buccaneers

When the Tampa Bay Buccaneers (7-8) and the Miami Dolphins (6-9) square off on Sunday, Dec. 28 at 1 p.m. ET, they will both be aiming to right the ship after losing their last tilt. The Buccaneers lost 23-20 to the Panthers, and the Dolphins are coming off a 45-21 loss to the Bengals.

• Game Preview: Tampa Bay Buccaneers at Miami Dolphins
• Projected Favorite: Buccaneers (54.36% win probability)
• Spread: Tampa Bay (-5.5)
• Total: 45.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Miami vs. Tampa Bay with FanDuel Sportsbook.

Bengals vs. Cardinals

Ja'Marr Chase and the Cincinnati Bengals (5-10) will host Trey McBride and the Arizona Cardinals (3-12) on Sunday at 1 p.m. ET, in a battle between two outstanding pass-catchers.

• Game Preview: Arizona Cardinals at Cincinnati Bengals
• Projected Favorite: Bengals (63.78% win probability)
• Spread: Cincinnati (-7)
• Total: 53.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Cincinnati vs. Arizona with FanDuel Sportsbook.

Panthers vs. Seahawks

The Seattle Seahawks (12-3) are scheduled to square off against the Carolina Panthers (8-7) at Bank of America Stadium on Sunday, Dec. 28 at 1 p.m. ET. Both teams won their previous game, as the Seahawks defeated the Rams 38-37, and the Panthers won 23-20 against the Buccaneers.

• Game Preview: Seattle Seahawks at Carolina Panthers
• Projected Favorite: Seahawks (69.20% win probability)
• Spread: Seattle (-7.5)
• Total: 42.5 -- Over: (-112) | Under: (-108)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Carolina vs. Seattle with FanDuel Sportsbook.

Jets vs. Patriots

One of the top quarterbacks in football will be on display when Drake Maye and the New England Patriots (12-3) visit the New York Jets (3-12) on Sunday, December 28, 2025.

• Game Preview: New England Patriots at New York Jets
• Projected Favorite: Patriots (72.62% win probability)
• Spread: New England (-12.5)
• Total: 42.5 -- Over: (-114) | Under: (-106)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New York vs. New England with FanDuel Sportsbook.

Titans vs. Saints

Don't count on a bunch of scoring when the New Orleans Saints (5-10) visit the Tennessee Titans (3-12) at 1 p.m. ET on Dec. 28, as both teams have scoring offenses that rank bottom-five in the NFL. The Saints are 29th (17.0 points per game), while the Titans are 30th (17.0 points per game).

• Game Preview: New Orleans Saints at Tennessee Titans
• Projected Favorite: Saints (65.83% win probability)
• Spread: New Orleans (-3)
• Total: 38.5 -- Over: (-118) | Under: (-104)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Tennessee vs. New Orleans with FanDuel Sportsbook.

Browns vs. Steelers

The Pittsburgh Steelers (9-6) are set to do battle against the Cleveland Browns (3-12) at Huntington Bank Field on Sunday, Dec. 28 at 1 p.m. ET. In their previous contests, the Steelers took down the Lions 29-24, and the Browns lost 23-20 to the Bills.

• Game Preview: Pittsburgh Steelers at Cleveland Browns
• Projected Favorite: Browns (50.37% win probability)
• Spread: Pittsburgh (-3)
• Total: 33.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Cleveland vs. Pittsburgh with FanDuel Sportsbook.

Raiders vs. Giants

Brock Bowers will lead the Las Vegas Raiders (2-13) into their battle against the New York Giants (2-13) at Allegiant Stadium on Sunday at 4:05 p.m. ET.

• Game Preview: New York Giants at Las Vegas Raiders
• Projected Favorite: Giants (56.83% win probability)
• Spread: Las Vegas (-1.5)
• Total: 41.5 -- Over: (-110) | Under: (-110)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Las Vegas vs. New York with FanDuel Sportsbook.

Bills vs. Eagles

At Highmark Stadium on Sunday, James Cook and the Buffalo Bills (11-4) meet Jalen Hurts and the Philadelphia Eagles (10-5) in a matchup featuring two of the brightest stars in football offensively, starting at 4:25 p.m. ET.

• Game Preview: Philadelphia Eagles at Buffalo Bills
• Projected Favorite: Bills (59.69% win probability)
• Spread: Buffalo (-1.5)
• Total: 43.5 -- Over: (-105) | Under: (-115)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Buffalo vs. Philadelphia with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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