Nebraska vs Michigan State Prediction, Odds, Picks, Best Bets for Week 6 2025

In college football action on Saturday, the Nebraska Cornhuskers play the Michigan State Spartans.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding today's NCAA football betting odds.

Nebraska vs Michigan State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Nebraska: (-450) | Michigan State: (+350)
• Spread: Nebraska: -11.5 (-108) | Michigan State: +11.5 (-112)
• Total: 49.5 -- Over: (-105) | Under: (-115)

Nebraska vs Michigan State Betting Trends

• Nebraska has won twice against the spread this year.
• Nebraska has covered every time (2-0) as an 11.5-point favorite or greater this year.
• This season, three of Nebraska's four games have go over the point total.
• Michigan State has but one win versus the spread this season.
• Michigan State is unbeaten ATS (1-0) as an 11.5-point underdog or greater this season.
• Of four Michigan State games so far this year, three have hit the over.

Nebraska vs Michigan State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cornhuskers win (75.5%)

Nebraska vs Michigan State Point Spread

Nebraska is favored by 11.5 points (-108 to cover) in this matchup. Michigan State, the underdog, is -112.

Nebraska vs Michigan State Over/Under

A combined point total of 49.5 has been set for Nebraska-Michigan State on Oct. 4, with the over at -105 and the under at -115.

Nebraska vs Michigan State Moneyline

Michigan State is a +350 underdog on the moneyline, while Nebraska is a -450 favorite.

Nebraska vs. Michigan State Points Insights

Nebraska vs. Michigan State Game Info

• Game day: Saturday, October 4, 2025
• Game time: 4 p.m. ET
• TV channel: Fox Sports 1
• Location: Lincoln, Nebraska
• Stadium: Memorial Stadium (Lincoln, NE)

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Check out even more in-depth Nebraska vs. Michigan State analysis on FanDuel Research.