Missouri vs Virginia Prediction, Odds, Picks, Best Bets for Gator Bowl 2025

The Missouri Tigers will face the Virginia Cavaliers in college football action on Saturday.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Missouri vs Virginia Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Missouri: (-192) | Virginia: (+158)
• Spread: Missouri: -4.5 (-106) | Virginia: +4.5 (-114)
• Total: 45.5 -- Over: (-104) | Under: (-118)

Missouri vs Virginia Betting Trends

• Against the spread, Missouri is 7-5-0 this year.
• Missouri's ATS record as 4.5-point or bigger favorites is 5-2.
• This season, six of Missouri's 12 games have hit the over.
• Against the spread, Virginia is 8-5-0 this year.
• As 4.5-point underdogs or greater, Virginia is 3-0 against the spread.
• Of 13 Virginia games so far this year, five have hit the over.

Missouri vs Virginia Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (67.1%)

Missouri vs Virginia Point Spread

Missouri is a 4.5-point favorite against Virginia. Missouri is -106 to cover the spread, and Virginia is -114.

Missouri vs Virginia Over/Under

The over/under for the Missouri versus Virginia game on Dec. 27 has been set at 45.5, with -104 odds on the over and -118 odds on the under.

Missouri vs Virginia Moneyline

Virginia is the underdog, +158 on the moneyline, while Missouri is a -192 favorite.

Missouri vs. Virginia Points Insights

Missouri vs. Virginia Game Info

• Game day: Saturday, December 27, 2025
• Game time: 7:30 p.m. ET
• TV channel: ABC
• Location: Jacksonville, Florida
• Stadium: EverBank Stadium

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Check out even more in-depth Missouri vs. Virginia analysis on FanDuel Research.