Mississippi State vs Southern Miss Prediction, Odds, Picks, Best Bets for Week 1 2025

The Saturday schedule in college football includes a matchup between the Mississippi State Bulldogs and the Southern Miss Golden Eagles.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Mississippi State vs Southern Miss Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Mississippi State: (-629) | Southern Miss: (+440)
• Spread: Mississippi State: -14.5 (-108) | Southern Miss: +14.5 (-112)
• Total: 61.5 -- Over: (-105) | Under: (-115)

Mississippi State vs Southern Miss Betting Trends

• Mississippi State had seven wins in 12 games against the spread last year.
• Mississippi State did not lose ATS (2-0) as a 14.5-point or more favorite last season.
• Mississippi State had eight of its 12 games go over the point total last season.
• Southern Miss had four wins in 12 games against the spread last season.
• Southern Miss went 3-3 as underdogs of 14.5 points or greater last season.
• In 12 Southern Miss games last year, five of them went over the total.

Mississippi State vs Southern Miss Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Bulldogs win (86.9%)

Mississippi State vs Southern Miss Point Spread

Mississippi State is favored by 14.5 points versus Southern Miss. Mississippi State is -108 to cover the spread, while Southern Miss is -112.

Mississippi State vs Southern Miss Over/Under

An over/under of 61.5 has been set for Mississippi State-Southern Miss on Aug. 30, with the over being -105 and the under -115.

Mississippi State vs Southern Miss Moneyline

Looking at the moneyline for Southern Miss-Mississippi State, Southern Miss is the underdog at +440, and Mississippi State is -629.

Mississippi State vs. Southern Miss Points Insights

• The Bulldogs had an average implied point total of 38.7 last season, which is 0.7 points higher than their implied total in Saturday's game (38).
• The 35.3-point average implied total last season for the Golden Eagles is 11.3 more points than the team's 24-point implied total in this matchup.

Mississippi State vs. Southern Miss Game Info

• Game day: Saturday, August 30, 2025
• Game time: 12 p.m. ET
• TV channel: ESPN
• Location: Hattiesburg, Mississippi
• Stadium: M.M. Roberts Stadium

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Check out even more in-depth Mississippi State vs. Southern Miss analysis on FanDuel Research.