Michigan vs Northwestern Prediction, Odds, Picks, Best Bets for Week 12 2025

In college football action on Saturday, the Michigan Wolverines take on the Northwestern Wildcats.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Michigan vs Northwestern Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Michigan: (-549) | Northwestern: (+410)
• Spread: Michigan: -12.5 (-106) | Northwestern: +12.5 (-114)
• Total: 41.5 -- Over: (-105) | Under: (-115)

Michigan vs Northwestern Betting Trends

• Against the spread, Michigan is 3-6-0 this year.
• Michigan owns one win ATS (1-4) as a 12.5-point favorite or greater this season.
• There have been four Michigan games (of nine) that hit the over this season.
• Northwestern is 6-3-0 against the spread this year.
• As a 12.5-point underdog or more, Northwestern has two wins ATS (2-1).
• Of nine Northwestern games so far this season, three have hit the over.

Michigan vs Northwestern Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Wolverines win (81.2%)

Michigan vs Northwestern Point Spread

Michigan is favored by 12.5 points (-106 to cover) in this matchup. Northwestern, the underdog, is -114.

Michigan vs Northwestern Over/Under

An over/under of 41.5 has been set for Michigan-Northwestern on Nov. 15, with the over being -105 and the under -115.

Michigan vs Northwestern Moneyline

Michigan is the favorite, -549 on the moneyline, while Northwestern is a +410 underdog.

Michigan vs. Northwestern Points Insights

Michigan vs. Northwestern Game Info

• Game day: Saturday, November 15, 2025
• Game time: 12 p.m. ET
• TV channel: FOX
• Location: Chicago, Illinois
• Stadium: Wrigley Field

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Michigan vs. Northwestern analysis on FanDuel Research.