Michigan State vs Detroit Mercy College Basketball Prediction, Odds, Picks, Best Bets for Nov. 21

The Detroit Mercy Titans (1-4) will try to end a three-game road slide when they visit the Michigan State Spartans (4-0) on November 21, 2025 at Jack Breslin Students Events Center.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Michigan State vs. Detroit Mercy Game Info and Odds

• Game day: Friday, November 21, 2025
• Game time: 6:30 p.m. ET
• TV channel: Big Ten Network
• Location: East Lansing, Michigan
• Arena: Jack Breslin Students Events Center

Michigan State is a 31.5-point favorite against Detroit Mercy on Friday and the over/under is set at 151.5 points. Keep reading for a few betting insights and trends if you plan to place a wager on the matchup.

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Michigan State vs. Detroit Mercy: ATS Betting Stats and Trends

• Michigan State compiled a 24-13-0 record against the spread last season.
• Detroit Mercy put together a 17-14-0 ATS record last season.
• The Spartans covered the spread in a lower percentage of their home games than road games last season. They covered 10 times in 16 games when playing at home, and they covered seven times in nine games when playing on the road.
• Against the spread, the Titans performed better at home (8-4-0) than away (8-9-0) last season.

Michigan State vs. Detroit Mercy Head-to-Head Comparison

• Offensively, Michigan State was the 78th-ranked team in the nation (77.7 points per game) last season. On defense, it was 44th (67.1 points allowed per game).
• On the boards, Michigan State was 10th-best in college basketball in rebounds (36.7 per game) last season. It was 28th in rebounds conceded (28.2 per game).
• Michigan State was 24th-best in the nation in assists (16.5 per game) last year.
• In terms of turnovers, Michigan State was 135th in college basketball in committing them (10.7 per game) last year. It was 265th in forcing them (10.4 per game).
• Detroit Mercy averaged 67.1 points per game (331st-ranked in college basketball) last year, while ceding 75.9 points per contest (292nd-ranked).
• Detroit Mercy pulled down 33.7 boards per game (72nd-ranked in college basketball) last year, while allowing 32 rebounds per contest (233rd-ranked).
• Detroit Mercy didn't post many assists last year, ranking 13th-worst in the nation with 10.8 assists per contest.
• Detroit Mercy averaged 12.5 turnovers per game (306th-ranked in college basketball) this year, while forcing 10 turnovers per contest (305th-ranked).

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