Mets vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 18

Odds updated as of 10:13 p.m.

The MLB's Thursday slate includes the New York Mets facing the San Diego Padres.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Mets vs Padres Game Info

• New York Mets (78-73) vs. San Diego Padres (82-69)
• Date: Thursday, September 18, 2025
• Time: 1:10 p.m. ET
• Venue: Citi Field -- Queens, New York
• Coverage: MLB Network, SNY, and SDPA

Mets vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYM: (-130) | SD: (+110)
• Spread: NYM: -1.5 (+146) | SD: +1.5 (-178)
• Total: 8.5 -- Over: (-122) | Under: (-100)

Mets vs Padres Probable Starting Pitchers

Probable Pitchers: Jonah Tong (Mets) - 1-2, 8.49 ERA vs Randy Vasquez (Padres) - 5-6, 3.72 ERA

This contest's pitching matchup is set, as the Mets will send Jonah Tong (1-2) to the mound, while Randy Vasquez (5-6) will answer the bell for the Padres. Tong and his team have a record of 1-2-0 against the spread when he starts. Tong's team has been victorious in 33.3% of the games he's started as the moneyline favorite with a record of 1-2. The Padres have gone 15-8-0 against the spread when Vasquez starts. The Padres have been the moneyline underdog in 15 of Vasquez's starts this season, and they went 8-7 in those games.

Mets vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (52.6%)

Mets vs Padres Moneyline

• San Diego is a +110 underdog on the moneyline, while New York is a -130 favorite at home.

Mets vs Padres Spread

• The Mets are hosting the Padres and are favored by 1.5 runs (+146 to cover) on the runline. San Diego is -178 to cover.

Mets vs Padres Over/Under

• An over/under of 8.5 has been set for Mets-Padres on Sept. 18, with the over being -122 and the under -100.

Bet on New York Mets vs. San Diego Padres on FanDuel today!

Mets vs Padres Betting Trends

• The Mets have been chosen as favorites in 102 games this year and have walked away with the win 59 times (57.8%) in those games.
• This year New York has won 44 of 80 games when listed as at least -130 on the moneyline.
• The Mets and their opponents have gone over in 67 of their 144 games with a total set by sportsbooks this season.
• The Mets have an against the spread record of 67-77-0 in 144 games with a line this season.
• The Padres have compiled a 30-33 record in games they were listed as the moneyline underdog (winning 47.6% of those games).
• San Diego has a 20-23 record (winning 46.5% of its games) when playing as a moneyline underdog of +110 or longer.
• The Padres have combined with opponents to hit the over on the total 65 times this season for a 65-81-3 record against the over/under.
• The Padres have put together an 80-69-0 record against the spread this season (covering 53.7% of the time).

Mets Player Leaders

• Juan Soto leads New York with 140 hits and an OBP of .395 this season. He has a .262 batting average and a slugging percentage of .523.
• Among all qualifying hitters in baseball, he ranks 60th in batting average, second in on-base percentage, and 11th in slugging.
• Francisco Lindor has an OPS of .794, fueled by an OBP of .340 and a team-best slugging percentage of .454 this season. He's batting .265.
• Among all qualifying players, he is 48th in batting average, 52nd in on-base percentage and 57th in slugging percentage.
• Lindor brings a five-game streak with at least one hit into this one. In his last five games he is hitting .316 with a double, a home run, three walks and an RBI.
• Pete Alonso has 156 hits this season and has a slash line of .268/.343/.515.
• Alonso heads into this game with three games in a row with at least one hit. In his last five games he is batting .250 with two home runs, a walk and five RBIs.
• Brandon Nimmo has 23 home runs, 83 RBI and a batting average of .262 this season.
• Nimmo takes a three-game hitting streak into this game. During his last five outings he is hitting .300 with a home run and three RBIs.

Padres Player Leaders

• Fernando Tatis Jr. is batting .262 with 27 doubles, two triples, 22 home runs and 86 walks. He's slugging .434 with an on-base percentage of .365.
• Including all the qualifying hitters in the big leagues, his batting average ranks 60th, his on-base percentage ranks 13th, and he is 71st in slugging.
• Manny Machado has collected 160 hits to pace his team. He has a batting average of .276 while slugging .463 with an on-base percentage of .338.
• Including all qualifying hitters, he is 30th in batting average, 56th in on-base percentage and 47th in slugging percentage.
• Luis Arraez has a team-best .386 slugging percentage.
• Ramon Laureano has 25 doubles, two triples, 23 home runs and 33 walks while batting .286.

Mets vs Padres Head to Head

• 9/16/2025: 8-3 NYM (Favorite: Mets, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 7/30/2025: 5-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/29/2025: 7-1 SD (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/28/2025: 7-6 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/25/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/24/2024: 7-1 NYM (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/23/2024: 7-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/22/2024: 8-3 NYM (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/16/2024: 11-6 NYM (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/15/2024: 5-1 NYM (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

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