Louisville vs Memphis College Basketball Prediction, Odds, Picks, Best Bets for Dec. 13

The Memphis Tigers (4-4) aim to continue a three-game win streak when they visit the Louisville Cardinals (8-1) on December 13, 2025 at KFC Yum! Center. The game airs on ESPN.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Memphis Game Info and Odds

• Game day: Saturday, December 13, 2025
• Game time: 3:30 p.m. ET
• TV channel: ESPN
• Location: Louisville, Kentucky
• Arena: KFC Yum! Center

If you plan to place a wager on Louisville-Memphis outing (in which Louisville is a 16.5-point favorite and the over/under has been set at 160.5 points), keep reading for some betting trends and insights for Saturday's game.

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Louisville vs. Memphis: ATS Betting Stats and Trends

• Louisville has covered six times in nine matchups with a spread this season.
• Memphis has compiled a 7-1-0 ATS record so far this year.
• The Cardinals covered the spread in a lower percentage of their home games than away games last season. They covered eight times in 17 games at home, and they covered nine times in 11 games when playing on the road.
• Last year, the Tigers were 6-9-0 at home against the spread (.400 winning percentage). Away, they were 6-6-0 ATS (.500).

Louisville vs. Memphis: Moneyline Betting Stats

• Louisville has come away with three wins in the four contests it has been listed as the moneyline favorite in this season.
• The Cardinals have yet to play a game this season with better moneyline odds than -2500.
• Memphis has gone 1-3 in games it was the underdog on the moneyline (winning 25% of those games).
• The Tigers have yet to play as a moneyline underdog of +1100 or longer.
• The moneyline set for this matchup implies Louisville has a 96.2% chance of coming away with a victory in the contest.

Louisville vs. Memphis Head-to-Head Comparison

• With 78.5 points scored per game and 69.5 points allowed last year, Louisville was 65th in the country offensively and 89th defensively.
• Last year, Louisville was 47th in college basketball in rebounds (34.6 per game) and 114th in rebounds conceded (30.2).
• Last season Louisville was ranked 148th in college basketball in assists with 13.9 per game.
• Last season, Louisville was 150th in the nation in turnovers committed (10.9 per game) and 93rd in turnovers forced (12.2).
• On offense, Memphis posted 79.9 points per game (40th-ranked in college basketball) last season. It ceded 73.4 points per contest at the other end (223rd-ranked).
• Memphis was 50th in the country with 34.5 rebounds per game. Meanwhile, it ranked 153rd with 30.8 rebounds allowed per contest.
• Last year Memphis ranked 111th in college basketball in assists, delivering 14.4 per game.
• Memphis came up short in the turnover area last year, ranking 17th-worst in college basketball with 13.5 turnovers per game. It ranked 62nd with 12.7 forced turnovers per contest.

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