Louisville vs Kentucky College Basketball Prediction, Odds, Picks, Best Bets for Nov. 11

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The Louisville Cardinals (2-0) square off against the Kentucky Wildcats (2-0) on November 11, 2025.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Kentucky Game Info and Odds

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Louisville win (71.8%)

Before making a bet on Tuesday's Louisville-Kentucky spread (Louisville -6.5) or total (174.5 points), read the betting insights and trends below.

Louisville won 20 games against the spread last season, while failing to cover 15 times.
Kentucky won 18 games against the spread last season, while failing to cover 18 times.
When the spread was set as 6.5 or more last season, Louisville (10-9) covered a lower percentage of those games when it was the favorite (52.6%) than Kentucky (3-2) did as the underdog (60%).
The Cardinals covered the spread in a lower percentage of their home games than away games last season. They covered eight times in 17 games when playing at home, and they covered nine times in 11 games when playing on the road.
Last year, the Wildcats were 10-8-0 at home against the spread (.556 winning percentage). Away, they were 4-6-0 ATS (.400).

Louisville finished 22-5 in games it was listed as the moneyline favorite last season (winning 81.5% of those games).
The Cardinals went 18-1 when they played as a moneyline favorite with odds of -245 or shorter (94.7%).
Last season, Kentucky was the underdog 13 times and won seven, or 53.8%, of those games.
The Wildcats had a record of 3-2 in games where bookmakers had them as underdogs of at least +198 on the moneyline.
The implied moneyline probability in this matchup gives Louisville a 71.0% chance to win.

Louisville was 65th in the country in points scored (78.5 per game) and 89th in points allowed (69.5) last season.
With 34.6 rebounds per game and 30.2 rebounds allowed, Louisville was 47th and 114th in the nation, respectively, last season.
Louisville was 148th in the nation in assists (13.9 per game) last year.
Louisville committed 10.9 turnovers per game last year and forced 12.2 per game, ranking 150th and 93rd, respectively, in the nation.
Kentucky was led by its offense last season, as it ranked seventh-best in the country by averaging 84.4 points per game. It ranked 315th in college basketball in points allowed (77.2 per contest).
With 34.1 boards per game, Kentucky was 63rd in college basketball. It ceded 32.1 rebounds per contest, which ranked 239th in college basketball.
Kentucky was one of the top teams in college basketball in terms of assists, as it collected 16.9 per game (17th-best in college basketball).
Kentucky committed 10.4 turnovers per game (108th-ranked in college basketball). It forced 9.9 turnovers per contest (312th-ranked).

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