Louisville vs Cincinnati College Basketball Prediction, Odds, Picks, Best Bets for Nov. 21

The Louisville Cardinals (4-0) bring a four-game win streak into a road matchup with the Cincinnati Bearcats (4-0), who have won four straight as well.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Cincinnati Game Info and Odds

• Game day: Friday, November 21, 2025
• Game time: 6:30 p.m. ET
• TV channel: ESPN2
• Location: Cincinnati, Ohio
• Arena: Heritage Bank Center

Before you bet on Friday's Louisville-Cincinnati spread (Louisville -8.5) or total (163.5 points), take a look at the betting trends and insights below.

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Louisville vs. Cincinnati: ATS Betting Stats and Trends

• Louisville put together a 20-15-0 ATS record last year.
• Cincinnati compiled a 17-18-0 record against the spread last season.
• Cincinnati covered the spread when it was an 8.5-point underdog or more 66.7% of the time. That's more often than Louisville covered as a favorite by 8.5 or more (47.1%).
• The Cardinals did a better job covering the spread on the road (9-2-0) than they did at home (8-9-0) last season.
• Last season, the Bearcats were 7-10-0 at home against the spread (.412 winning percentage). On the road, they were 7-6-0 ATS (.538).

Louisville vs. Cincinnati: Moneyline Betting Stats

• Louisville won 22 of the 27 games it was listed as the moneyline favorite last season (81.5%).
• The Cardinals won all 15 games they played as a moneyline favorite with odds of -450 or shorter.
• Cincinnati was underdogs in nine games last season and won one (11.1%) of those contests.
• The Bearcats played as an underdog of +340 or more twice last season and lost both games.
• Based on this contest's moneyline, Louisville's implied win probability is 81.8%.

Louisville vs. Cincinnati Head-to-Head Comparison

• At 78.5 points scored per game and 69.5 points conceded last season, Louisville was 65th in the country offensively and 89th defensively.
• On the boards, Louisville was 47th in the nation in rebounds (34.6 per game) last year. It was 114th in rebounds allowed (30.2 per game).
• Last season Louisville was ranked 148th in the nation in assists with 13.9 per game.
• In terms of turnovers, Louisville was 150th in the country in committing them (10.9 per game) last season. It was 93rd in forcing them (12.2 per game).
• Cincinnati put up 71.2 points per game (255th-ranked in college basketball) last season, while ceding 66.2 points per contest (33rd-ranked).
• Cincinnati averaged 32.0 boards per game (179th-ranked in college basketball) last season, while allowing 29.9 rebounds per contest (94th-ranked).
• Last year Cincinnati ranked 148th in college basketball in assists, delivering 13.9 per game.
• Cincinnati was 45th in college basketball with 9.7 turnovers per game last year. Meanwhile, it ranked 74th with 12.5 forced turnovers per game.

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