Louisville vs Boston College Prediction, Odds, Picks, Best Bets for Week 9 2025

The Louisville Cardinals are among the college football teams in action on Saturday, up against the Boston College Eagles.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Louisville vs Boston College Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Louisville: (-4545) | Boston College: (+1600)
• Spread: Louisville: -25.5 (-110) | Boston College: +25.5 (-110)
• Total: 54.5 -- Over: (-110) | Under: (-110)

Louisville vs Boston College Betting Trends

• Louisville has posted two wins against the spread this year.
• Louisville is winless ATS (0-2) as a 25.5-point favorite or greater this season.
• This season, three of Louisville's six games have go over the point total.
• Boston College owns two wins against the spread this season.
• Boston College has played seven games this year, and five of them have hit the over.

Louisville vs Boston College Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (93.3%)

Louisville vs Boston College Point Spread

Boston College is listed as an underdog by 25.5 points (-110 odds), and Louisville, the favorite, is -110 to cover.

Louisville vs Boston College Over/Under

An over/under of 54.5 has been set for Louisville-Boston College on Oct. 25, with the over being -110 and the under -110.

Louisville vs Boston College Moneyline

Louisville is a -4545 favorite on the moneyline, while Boston College is a +1600 underdog.

Louisville vs. Boston College Points Insights

Louisville vs. Boston College Game Info

• Game day: Saturday, October 25, 2025
• Game time: 7:30 p.m. ET
• TV channel: ACC Network
• Location: Louisville, Kentucky
• Stadium: L&N Federal Credit Union Stadium

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Check out even more in-depth Louisville vs. Boston College analysis on FanDuel Research.