The Sunday schedule in the NFL includes a matchup between the Detroit Lions and the Indianapolis Colts.

Get the latest NFL odds ahead of this game on FanDuel Sportsbook.

Lions vs Colts Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Lions win (65.4%)

Lions vs Colts Point Spread

The Lions are 7.5-point favorites against the Colts. The Lions are -104 to cover the spread, while the Colts are -118 to cover as a 7.5-point underdog.

Lions vs Colts Over/Under

The over/under for the Lions versus Colts game on Nov. 24 has been set at 50.5, with -105 odds on the over and -115 odds on the under.

Lions vs Colts Moneyline

The moneyline numbers for Lions vs. Colts reveal Detroit as the favorite (-370) and Indianapolis as the underdog (+295) despite being the home team.

Lions vs Colts Betting Trends

• Detroit's record against the spread is 8-2-0.
• The Lions have won twice ATS (2-1) as a 7.5-point favorite or more this year.
• This season, six of the Lions' 10 games have gone over the point total.
• The Colts are 8-3-0 against the spread this season.
• This year, five of the Colts' 11 games have gone over the point total.

Lions vs Colts Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-370) | IND: (+295)
• Spread: DET: -7.5 (-104) | IND: +7.5 (-118)
• Total: 50.5 -- Over: (-105) | Under: (-115)

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