Lions vs Bengals Prediction, Odds, Picks, Best Bets for NFL Week 5

On Sunday in the NFL, the Detroit Lions are playing the Cincinnati Bengals.

We've got you covered, in terms of the vital information about NFL betting lines, before you make your wager on FanDuel Sportsbook.

Lions vs Bengals Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Lions win (76.9%)

Lions vs Bengals Point Spread

The Lions are 10.5-point favorites against the Bengals. The Lions are -104 to cover the spread, while the Bengals are -118 to cover as a 10.5-point underdog.

Lions vs Bengals Over/Under

The over/under for Lions-Bengals on Oct. 5 is 48.5. The over is -115, and the under is -105.

Lions vs Bengals Moneyline

Cincinnati is the underdog, +450 on the moneyline, while Detroit is a -599 favorite despite being on the road.

Lions vs Bengals Betting Trends

• Against the spread, Detroit is 3-1-0 this season.
• Two of the Lions' four games have hit the over.
• The Bengals have one win against the spread this year.
• Two of the Bengals' four games in 2025 have gone over the point total.

Check out even more in-depth Lions vs. Bengals analysis on FanDuel Research.

Lions vs Bengals Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-599) | CIN: (+450)
• Spread: DET: -10.5 (-104) | CIN: +10.5 (-118)
• Total: 48.5 -- Over: (-115) | Under: (-105)

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