Lions vs 49ers Prediction, Odds, Picks, Best Bets for NFL Week 17 Monday Night Football

The Detroit Lions will face the San Francisco 49ers in NFL action on Monday.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NFL moneyline insights you need to know.

Lions vs 49ers Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Lions win (67.6%)

Lions vs 49ers Point Spread

The Lions are 3.5-point favorites against the 49ers. The Lions are -105 to cover the spread, while the 49ers are -115 to cover as a 3.5-point underdog.

Lions vs 49ers Over/Under

A total of 50.5 points has been set for the Lions-49ers game on Dec. 30, with the over available at -110 and the under at -110.

Lions vs 49ers Moneyline

The Lions vs 49ers moneyline has Detroit as a -198 favorite, while San Francisco is a +166 underdog at home.

Lions vs 49ers Betting Trends

• Detroit has covered the spread 10 times in 15 games.
• Against the spread as 3.5-point favorites or more, the Lions are 7-4.
• There have been nine Lions games (out of 15) that went over the total this year.
• The 49ers have five wins in 15 contests against the spread this season.
• San Francisco has no wins ATS (0-2) as a 3.5-point underdog or greater this season.
• Out of 15 49ers games so far this season, nine have hit the over.

Lions vs 49ers Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-198) | SF: (+166)
• Spread: DET: -3.5 (-105) | SF: +3.5 (-115)
• Total: 50.5 -- Over: (-110) | Under: (-110)

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