Lakers vs. Spurs Prediction, Odds, Picks, Best Bets for Dec. 10

Lakers vs. Spurs Game Info

• Date: Wednesday, December 10, 2025
• Time: 10 p.m. ET
• Venue: Crypto.com Arena -- Los Angeles, California
• Coverage: Amazon Prime Video and SportsNet LA

The San Antonio Spurs (16-7) are 5.5-point underdogs against the Los Angeles Lakers (17-6) at Crypto.com Arena on Wednesday, December 10, 2025. The game begins at 10 p.m. ET on Amazon Prime Video and SportsNet LA. The matchup's point total is 237.5.

Lakers vs. Spurs Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Lakers vs. Spurs Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Lakers win (63.1%)

Lakers vs. Spurs Betting Trends

• The Lakers have compiled a 15-8-0 record against the spread this season.
• In the Spurs' 23 games this season, they have 10 wins against the spread.
• This season, 16 of the Lakers' games have gone over the point total.
• Spurs games this year have gone over the point total 13 times in 23 opportunities (56.5%).
• Against the spread, Los Angeles has fared worse when playing at home, covering six times in 10 home games, and nine times in 13 road games.
• Looking at point totals, the Lakers hit the over more consistently at home, as they've exceeded the total 10 times in 10 opportunities this season (100%). On the road, they have hit the over six times in 13 opportunities (46.2%).
• Against the spread, San Antonio has performed better at home (6-3-2) than on the road (4-7-1).
• In 2025-26 a lower percentage of the Spurs' games have finished above the over/under at home (45.5%, five of 11) than on the road (66.7%, eight of 12).

Lakers Leaders

• Luka Doncic's numbers on the season are 35.0 points, 9.2 boards and 9.1 assists per game, shooting 47.2% from the field and 33.5% from beyond the arc, with an average of 3.6 made treys (third in league).
• Austin Reaves averages 28.4 points, 5.5 boards and 6.7 assists, shooting 50.9% from the field and 37.0% from downtown, with 2.9 made 3-pointers per contest.
• Deandre Ayton's numbers on the season are 15.3 points, 8.8 rebounds and 0.9 assists per game, shooting 70.6% from the floor (second in NBA).
• Rui Hachimura is averaging 14.0 points, 0.8 assists and 3.9 rebounds.
• Jake Laravia's numbers on the season are 8.9 points, 3.8 boards and 1.8 assists per contest, shooting 46.3% from the floor and 33.3% from beyond the arc, with an average of 1.0 made treys.

Spurs Leaders

• Devin Vassell averages 15.7 points for the Spurs, plus 3.7 boards and 2.4 assists.
• Per game, De'Aaron Fox gets the Spurs 24.3 points, 3.7 boards and 6.5 assists. He also averages 1.3 steals and 0.3 blocks.
• Keldon Johnson averages 13.0 points, 6.5 boards and 1.8 assists. He is draining 57.5% of his shots from the floor (10th in league).
• Per game, Harrison Barnes provides the Spurs 13.4 points, 3.4 boards and 2.2 assists, plus 1.0 steal and 0.2 blocks.
• Julian Champagnie averages 11.2 points, 5.3 boards and 1.4 assists. He is sinking 42.0% of his shots from the floor and 37.8% from 3-point range, with 2.3 triples per contest.

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