Illinois vs Northwestern Prediction, Odds, Picks, Best Bets for Week 14 2025

The Illinois Fighting Illini will face the Northwestern Wildcats in college football action on Saturday.

We've got you covered, in terms of the vital information regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Illinois vs Northwestern Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Illinois: (-290) | Northwestern: (+235)
• Spread: Illinois: -7.5 (-104) | Northwestern: +7.5 (-118)
• Total: 44.5 -- Over: (-110) | Under: (-110)

Illinois vs Northwestern Betting Trends

• Illinois is 7-4-0 against the spread this season.
• Against the spread as 7.5-point or better favorites, Illinois is 5-1.
• This season, five of Illinois' 11 games have hit the over.
• Northwestern is 7-4-0 against the spread this year.
• Northwestern is 4-1 as 7.5-point or bigger underdogs in 2025.
• Northwestern has played 11 games this season, and five of them have gone over the total.

Illinois vs Northwestern Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Illini win (75.8%)

Illinois vs Northwestern Point Spread

Illinois is favored by 7.5 points (-104 to cover) in this matchup. Northwestern, the underdog, is -118.

Illinois vs Northwestern Over/Under

The over/under for the Illinois versus Northwestern game on Nov. 29 has been set at 44.5, with -110 odds on the over and -110 odds on the under.

Illinois vs Northwestern Moneyline

The Illinois vs Northwestern moneyline has Illinois as a -290 favorite, while Northwestern is a +235 underdog.

Illinois vs. Northwestern Points Insights

Illinois vs. Northwestern Game Info

• Game day: Saturday, November 29, 2025
• Game time: 7:30 p.m. ET
• TV channel: FOX
• Location: Champaign, Illinois
• Stadium: Memorial Stadium (Champaign, IL)

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Check out even more in-depth Illinois vs. Northwestern analysis on FanDuel Research.