Houston vs West Virginia Prediction, Odds, Picks, Best Bets for Week 10 2025

The Saturday slate in college football includes a matchup between the Houston Cougars and the West Virginia Mountaineers.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info about today's NCAA football betting odds.

Houston vs West Virginia Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Houston: (-500) | West Virginia: (+385)
• Spread: Houston: -13.5 (-110) | West Virginia: +13.5 (-110)
• Total: 49.5 -- Over: (-110) | Under: (-110)

Houston vs West Virginia Betting Trends

• Houston has beaten the spread six times in eight games.
• On the season, Houston is 3-0 as 13.5-point or better favorites.
• This season, five of Houston's eight games have hit the over.
• West Virginia is 4-4-0 against the spread this year.
• As a 13.5-point underdog or more, West Virginia has two wins ATS (2-1).
• West Virginia has played eight games this season, and three of them have hit the over.

Houston vs West Virginia Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cougars win (80.6%)

Houston vs West Virginia Point Spread

Houston is favored by 13.5 points over West Virginia. Houston is -110 to cover the spread, with West Virginia being -110.

Houston vs West Virginia Over/Under

The over/under for Houston-West Virginia on Nov. 1 is 49.5. The over is -110, and the under is -110.

Houston vs West Virginia Moneyline

West Virginia is the underdog, +385 on the moneyline, while Houston is a -500 favorite.

Houston vs. West Virginia Points Insights

Houston vs. West Virginia Game Info

• Game day: Saturday, November 1, 2025
• Game time: 12 p.m. ET
• TV channel: Fox Sports 1
• Location: Houston, Texas
• Stadium: TDECU Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Houston vs. West Virginia analysis on FanDuel Research.