Hornets vs. Cavaliers Prediction, Odds, Picks, Best Bets for Jan. 21

Hornets vs. Cavaliers Game Info

• Date: Wednesday, January 21, 2026
• Time: 7 p.m. ET
• Venue: Spectrum Center -- Charlotte, North Carolina
• Coverage: ESPN, FDSSE, and FDSOH

The Charlotte Hornets (16-27) are slight underdogs (by 2.5 points) to break a four-game home losing streak when they host the Cleveland Cavaliers (24-20) on Wednesday, January 21, 2026 at 7 p.m. ET. The point total in the matchup is set at 236.5.

Hornets vs. Cavaliers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Hornets vs. Cavaliers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Cavaliers win (56.4%)

Hornets vs. Cavaliers Betting Trends

• The Cavaliers have compiled a 16-28-0 record against the spread this season.
• The Hornets are 25-18-0 against the spread this season.
• This season, 21 of the Cavaliers' games have gone over the point total out of 43 chances.
• Hornets games this season have gone over the point total 18 times in 43 opportunities (41.9%).
• At home, Cleveland owns a worse record against the spread (8-17-0) compared to its ATS record on the road (8-11-0).
• The Cavaliers have exceeded the over/under in 10 of 25 home games (40%). They've fared better in road games, topping the total in 11 of 19 matchups (57.9%).
• In 2025-26 against the spread, Charlotte has a lower winning percentage at home (.579, 11-8-0 record) than on the road (.583, 14-10-0).
• Hornets games have gone above the over/under less frequently at home (seven times out of 19) than away (11 of 24) this year.

Cavaliers Leaders

• Donovan Mitchell's numbers on the season are 29 points, 4.8 rebounds and 5.7 assists per game, shooting 48.5% from the field and 38.4% from downtown, with an average of 3.8 made 3-pointers (second in NBA).
• Evan Mobley's numbers on the season are 17.8 points, 8.6 boards and 4.2 assists per contest, shooting 51.7% from the floor and 32.6% from downtown, with an average of 1.2 made 3-pointers.
• Jaylon Tyson averages 13.5 points, 5.4 boards and 2.1 assists.
• Jarrett Allen is averaging 13.5 points, 2.1 assists and 7.9 rebounds.
• De'Andre Hunter averages 14.1 points, 4.4 rebounds and 2.2 assists, shooting 42.6% from the floor and 31% from downtown, with 1.7 made 3-pointers per contest.

Hornets Leaders

• Per game, Miles Bridges gives the Hornets 19.1 points, 6.4 rebounds and 3.6 assists. He also averages 0.5 steals and 0.5 blocks.
• Kon Knueppel's numbers on the season are 19 points, 5.3 rebounds and 3.5 assists per contest. He is making 48.8% of his shots from the floor and 43.5% from 3-point range, with an average of 3.4 triples (sixth in NBA).
• The Hornets get 19.9 points per game from LaMelo Ball, plus 5 rebounds and 7.6 assists.
• The Hornets get 8.1 points per game from Moussa Diabate, plus 8.4 boards and 1.5 assists.
• Per game, Brandon Miller gets the Hornets 19.8 points, 4.3 boards and 3.4 assists, plus 0.9 steals and 1 block.

For more NBA betting insights, check out FanDuel Research's NBA home page.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Watch FanDuel TV's NBA show "Run It Back" with Lou Williams, Michelle Beadle, DeMarcus "Boogie" Cousins and Chandler Parsons weekdays at 10am ET on FanDuel TV, the Run It Back YouTube page, or download the podcast here: fanduel.com/research/tv-and-podcast.