Odds updated as of 10:11 p.m.

The MLB slate on Friday includes the San Francisco Giants facing the St. Louis Cardinals.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Giants vs Cardinals Game Info

• San Francisco Giants (79-80) vs. St. Louis Cardinals (81-78)
• Date: Friday, September 27, 2024
• Time: 10:15 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA

Giants vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-132) | STL: (+112)
• Spread: SF: -1.5 (+164) | STL: +1.5 (-200)
• Total: 7.5 -- Over: (-100) | Under: (-122)

Giants vs Cardinals Probable Starting Pitchers

Probable Pitchers: Landen Roupp (Giants) - 1-1, 2.70 ERA vs Miles Mikolas (Cardinals) - 9-11, 5.35 ERA

The Giants will give the nod to Landen Roupp (1-1, 2.70 ERA), who is eyeing win No. 2 on the season, and the Cardinals will counter with Miles Mikolas (9-11, 5.35 ERA). Roupp and his team have covered in each of his three starts with a spread this season. This will be Roupp's first game as the moneyline favorite this season. The Cardinals are 17-14-0 against the spread when Mikolas starts. The Cardinals have a 12-10 record in Mikolas' 22 starts this season when they were the underdog on the moneyline.

Giants vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (58.6%)

Giants vs Cardinals Moneyline

• The Giants vs Cardinals moneyline has San Francisco as a -132 favorite, while St. Louis is a +112 underdog on the road.

Giants vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the Giants. The Cardinals are -200 to cover, and the Giants are +164.

Giants vs Cardinals Over/Under

• Giants versus Cardinals on Sept. 27 has an over/under of 7.5 runs, with the odds on the over -100 and the under set at -122.

Bet on San Francisco Giants vs. St. Louis Cardinals on FanDuel today!

Giants vs Cardinals Betting Trends

• The Giants have won in 44, or 56.4%, of the 78 contests they have been named as odds-on favorites in this year.
• San Francisco has a record of 29-20 in contests when sportsbooks favor them by -132 or more on the moneyline.
• The Giants and their opponents have gone over the total this season in 80 of their 157 opportunities.
• The Giants have posted a record of 78-79-0 against the spread this season.
• The Cardinals are 38-41 in games they were the underdog on the moneyline (winning 48.1% of those games).
• St. Louis has a 13-21 record (winning just 38.2% of its games) when playing as a moneyline underdog of +112 or longer.
• The Cardinals have combined with opponents to hit the over on the total 70 times this season for a 70-82-2 record against the over/under.
• The Cardinals have put together a 74-80-0 record ATS this season (covering 48.1% of the time).

Giants Player Leaders

• Matt Chapman leads San Francisco OPS (.787) this season. He has a .246 batting average, an on-base percentage of .328, and a slugging percentage of .459.
• Among all qualified batters, he ranks 84th in batting average, his on-base percentage ranks 58th, and he is 39th in slugging.
• Heliot Ramos has 127 hits, which is tops among San Francisco batters this season. He's batting .273 with 48 extra-base hits. He's also slugging .476 with an on-base percentage of .326.
• Among qualifying batters, he is 36th in batting average, 62nd in on-base percentage and 25th in slugging percentage.
• Ramos enters this matchup looking to extend his three-game hit streak. During his last five outings he is batting .318 with a double, a home run, a walk and two RBI.
• Michael Conforto has collected 101 base hits, an OBP of .306 and a slugging percentage of .450 this season.
• Conforto enters this matchup with four games in a row with at least one hit. In his last five games he is hitting .238 with two doubles, two home runs, a walk and four RBI.
• Mike Yastrzemski has been key for San Francisco with 97 hits, an OBP of .305 plus a slugging percentage of .440.
• Yastrzemski takes a two-game hitting streak into this matchup. During his last five outings he is hitting .190 with a double, a home run and three RBI.

Cardinals Player Leaders

• Brendan Donovan has a .338 on-base percentage and a .409 slugging percentage, both team-best marks for the Cardinals. He's batting .274.
• Including all the qualified players in the majors, his batting average is 33rd, his on-base percentage ranks 39th, and he is 78th in slugging.
• Alec Burleson's 142 hits pace his team. He has a batting average of .265 while slugging .421 with an on-base percentage of .308.
• He is currently 47th in batting average, 103rd in on-base percentage and 70th in slugging percentage among all qualifying hitters.
• Nolan Arenado is batting .269 with 22 doubles, 16 home runs and 44 walks.
• Masyn Winn has 30 doubles, five triples, 15 home runs and 40 walks while batting .267.

Giants vs Cardinals Head to Head

• 6/23/2024: 5-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/22/2024: 9-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/20/2024: 6-5 STL (Favorite: Giants, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/14/2023: 8-5 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/13/2023: 11-3 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/12/2023: 4-3 SF (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/27/2023: 6-0 STL (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 4/26/2023: 7-3 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/25/2023: 5-4 SF (Favorite: Giants, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/24/2023: 4-0 SF (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)

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